MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review.
Smolle MA, Leithner A, Posch F, Szkandera J, Liegl-Atzwanger B, Pichler M · International journal of molecular sciences
Sarcoma subtypes
Abstract
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
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Publication type
Source: PubMed, PMID 28895916. Always confirm details with the original publication or your oncologist.