Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine.
Dermawan JK, Rubin BP · Annual review of pathology
Sarcoma subtypes
Abstract
KIT PDGFRA Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological genesis of GISTs, identification of the various primary activating driver mutations (focusing onand), oncogene addiction and targeted therapies with imatinib and other tyrosine kinase inhibitors, and the subsequent characterization of the various mechanisms of drug resistance. We illustrate how GIST has become a quintessential paradigm for personalized medicine.
Shown exactly as published on PubMed. Your oncologist is the right person to judge whether these findings apply to your situation.
Publication type
Source: PubMed, PMID 34736340. Always confirm details with the original publication or your oncologist.