Advances in Radiation Oncology in Soft Tissue Sarcoma.

PURPOSE: To review recent advances with radiation therapy (RT) for soft tissue sarcomas (STS).

RECENT FINDINGS: Newer data showcases hypofractionated preoperative RT for soft tissue sarcomas treated with surgery to be safe and effective, however, long-term follow up data is pending. Hypofractionated and dose-escalated RT in patients with unresectable STS is also being studied, for which we remain optimistic given advances in RT planning approaches. SFRT may also be considered in select cases to improve tumor control outcomes. Finally, for patients requiring high doses of RT adjacent to critical structures, re-irradiation, and to minimize risk of secondary malignancy in our younger population, particle therapy may be beneficial. We summarize a number of recent advances in RT for STS that can benefit patients with localized disease as well as for patients with advanced disease.