Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting.
Jeys LM, Morris GV, Kurisunkal VJ, Botello E, Boyle RA, Ebeid W, Houdek MT, Puri A, Ruggieri P, Brennan B, BOOM Consensus Meeting Participants, Laitinen MK, Abad Repiso S, Abdelbary H, Abiad Mejia A, Abood AA, Abril Martin JC, Abudu A, Abu Elhamd A, Acosta M, Ae K, Agarwal M, Ajit Singh V, Akiyama T, Alshaygy I, Albergo JI, Alexander J, Alfaro PA, Alpan B, Amaya-Valero J, Anderson M, Andreou D, Annabell L, Anthony C, Aoude A, Arteagoitia-Colino I, Asavamongkolkul A, Aston W, Asua Mentxaka L, Azzopardi C, Baad-Hansen T, Badr IT, Baixauli-Garcia F, Baker G, Balach T, Baldi GG, Barry J, Basile G, Bastoni S, Basuki M, Bauer H, Bayliss L, Becker RG, Bedi A, Benevenia J, Bengoa F, Bergh P, Bergovec M, Bernthal N, Binitie O, Boddie D, Boffano M, Bonilla Huertas P, Borgognoni AB, Botchu R, Bramer J, Brar R, Branford-White H, Broekhuis D, Broida SE, Budny T, Burke ZD, Cabrolier J, Calvo-Haro JA, Calvo Tapies JR, Cardoso R, Carey Smith R, Carvallo PI, Casales Fresenga N, Casanova JM, Ceballos O, Cebrian Parra JL, Chacon Cartaya S, Chan CM, Cho YJ, Choong P, Chung YG, Ciechanowicz D, Clara-Altamirano MA, Clever D, Colina SM, Consuegra L, Couch C, Cribb G, Cuervo C, Cusick LA, Dadia S, Dagher T, Dammerer D, Davies M, Davies N, de la Rosa Martino LP, de Santos de la Fuente FJ, de Vaal M, Deckers C, Delgado Obando J, Deo S, Deventer N, Di Bella C, Domson G, Donati DM, Dorleijn DM, Du Toit J, Dunne D, Duran Ciarrochi R, Ekman E, El Ghoneimy AM, Endo M, Eralp L, Etaiwi M, Evans S, Evrard R, Eward W, Farese A, Ferguson PC, Ferreira Cardoso PF, Fiorenza F, Flint M, Flores H, Freitas J, Fuchs B, Fujiwara T, Funovics PT, Galli Serra M, Gamie Z, Garces-Zarzalejo C, Gazendam A, Gebert C, Gerbers JG, Gerrand C, Abou-Nouar G, Ghert M, Ghosh KM, Gibbons M, Gomez-Mier LC, Gomez-Vallejo J, Gomez-Mascard A, Gonzalez MR, Gonzalez-Lizan F, Gosheger G, Goudie S, Goulding K, Goumenos SD, Griffin A, Gulia A, Gupta S, Gupta A, Guzman M, Haitham M, Hardes J, Hardoy F, Hasan Y, Hauer G, Havard H, Haydon R, Healey J, Hernandez Gonzalez N, Hernandez-Lopez A, Hesla A, Hess M, Hilton T, Hongsaprabhas C, Hornicek F, Hosking K, Houghton E, Idowu OK, Ippolito J, Isler M, Iwata S, Jagiello J, Jenkins N, Jenkins T, Jeys C, Jeys T, Johnson L, Johnston A, Joo MW, Jutte PC, Kaldas K, Kamat A, Kannan S, Kapanci B, Khan Z, Kobayashi H, Kollender Y, Koob S, Kotrych D, Kyte R, Lamo de Espinosa JM, Lazarides AL, Le Nail LR, Legosz P, Lehner B, Leithner A, Lejoly M, Lewis VO, Lin P, Linares F, Lozano-Calderon SA, Mahendra A, Mahyudin F, Mandia Mancebo FJ, Torrejon SM, Marx C, Mascard E, Mattei JC, McCullough L, McMahon S, Medellin Rincon MR, Miller B, Miwa S, Molina Uribe G, Moon B, Morgan-Jones R, Moriel Garcesco DJ, Morris C, Morrison S, Mottard S, Moura M, Muster L, Nakayama R, Narhari P, Navas A, Nayak P, Neugebauer J, Newman ET, Nieminen J, Nyqvist E, Nystrom L, O'Reilly-Harbidge S, O'Toole G, Oliveira V, Olivier A, Omar M, Ortiz-Cruz EJ, Ozger H, Ozkan K, Pala E, Palmerini E, Pang G, Papagelopoulos P, Paraliticci G, Parry MC, Patton S, Peake D, Peiro Ibanez A, Perez Munoz I, Perianayagam GR, Petersen MM, Ploegmakers J, Pollock R, Powell G, Pretell J, Puetzler J, Qamar F, Raja A, Rajasekaran RB, Ramkumar D, Randall RL, Rankin KS, Raskin KA, Rassppan K, Repsa L, Ropars M, Rose P, Sadek W, Salcedo G, Saleemi A, Sambri A, Sar H, Scanferla R, Schubert T, Schwarze J, Scoccianti G, Scrimshire A, Sekita T, Shehadeh A, Shoaib A, Shreemal B, Shumelinsky F, Siegel G, Silveri C, Silverwood R, Sinnaeve F, Sison J, Slade A, Smolle MA, Snyman F, Sommerville S, Sood S, Spiguel A, St-Yves H, Staals EL, Stacchiotti S, Stavropoulos N, Steadman P, Stevenson JD, Sullivan M, Sys G, Szostakowski B, Tamburini A, Taniguchi Y, Temple T, Theil C, Thorkildsen J, Tibbo M, Tillman R, Toda Y, Tootsi K, Torner Rubies F, Traub F, Trikoupis I, Tsagkozis P, Tsoi K, Tsuchiya H, Vainio VM, Valcarcel A, Valencia J, Van Beeck A, Van de Sande M, Van Den Berghe T, Van de Geest I, Van der Heijden L, Van der Wal R, Van Langevelde K, Vaz G, Velez Villa R, Verspoor F, Verstraete K, Visgauss J, Vyrva O, Wafa H, Walter S, Wan Ismail WF, Wang E, Wang PQ, Warnock D, Werier J, Weschenfelder W, Wong KC, Woulthuyzen-Bakker M, Wunder J, Wysinghe I, Yamamoto N, Ye Z, Yoon SJ, Zainul Abidin S, Zamora T, Zecchetto P, Zhang L, Zumarraga JP, Campanacci DA · The bone & joint journal
Sarcoma subtypes
Abstract
AIMS: The Birmingham Orthopaedic Oncology Meeting (BOOM), held in January 2024, convened 309 delegates from 53 countries to discuss and refine 21 consensus statements on the optimal management of chondrosarcoma.
METHODS: With representation from Europe (43%; n = 133), North America (17%; n = 53), South America (16%; n = 49), Asia (13%; n = 40), Australasia (5%; n = 16), the Middle East (4%; n = 12), and Africa (2%; n = 6), the combined experience of treating bone sarcomas among attendees totalled approximately 30,000 cases annually, equivalent to 66 years of experience in the UK alone. The meeting's process began with the formation of a local organizing committee, regional leads, and a scientific committee comprising representatives from 150 specialist units across 47 countries. Supported by major orthopaedic oncology organizations, the meeting used a modified Delphi process to develop consensus statements through online questionnaires, thematic groupings, narrative reviews, and anonymous pre-meeting polling.
RESULTS: Strong (> 80%) consensus was achieved on 19 out of 21 statements, reflecting agreement among delegates. Key areas of consensus included the role of radiology in diagnosis and surveillance, the management of locally recurrent disease, and the treatment of dedifferentiated chondrosarcoma. Notably, there was agreement that routine chemotherapy has no role in chondrosarcoma treatment, and radiological surveillance is safe for intraosseous chondrosarcomas. Despite the overall consensus, areas of controversy remain, particularly regarding the treatment of atypical cartilage tumours and surgical margins. These unresolved issues underscore the need for further research and collaboration within the orthopaedic oncology community.
CONCLUSION: BOOM represents the largest global consensus meeting in orthopaedic oncology, providing valuable guidance for clinicians managing chondrosarcoma worldwide. The consensus statements offer a reference for clinical practice, highlight key research priorities, and aim to improve patient outcomes on a global scale.
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Publication type
Source: PubMed, PMID 39889743. Always confirm details with the original publication or your oncologist.