Molecular Targets in Alveolar Rhabdomyosarcoma: A Narrative Review of Progress and Pitfalls.
Ziemba B, Lukow K · International journal of molecular sciences
Sarcoma subtypes
Abstract
PAX3/7-FOXO1 YAP TFAP2B CDK4 FGFR MET FOXF1 ETS1 Alveolar rhabdomyosarcoma (ARMS) is a highly aggressive pediatric soft-tissue sarcoma driven byfusion proteins. Despite intensive multimodal therapy, outcomes remain poor for patients with fusion-positive ARMS. This review integrates recent advances in the molecular pathogenesis of ARMS, highlighting key diagnostic and therapeutic targets. We discuss the central role of fusion proteins in transcriptional reprogramming, impaired myogenic differentiation, and super-enhancer activation. Emerging biomarkers (,, P-cadherin) and oncogenic kinases (Aurora A,, PLK1) are evaluated alongside receptor tyrosine kinases (,) and transcription factors involved in metabolic rewiring (,). Additionally, we examine immunotherapeutic strategies, epigenetic modifiers, and noncoding RNAs as potential therapeutic avenues. Together, these insights provide a comprehensive framework for developing biomarker-guided, multi-targeted therapies to improve outcomes in ARMS.
Shown exactly as published on PubMed. Your oncologist is the right person to judge whether these findings apply to your situation.
Publication type
Source: PubMed, PMID 40508013. Always confirm details with the original publication or your oncologist.