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Review2025

Osteosarcoma.

Gross JM, Hameed M · Surgical pathology clinics

Sarcoma subtypes

Abstract

The diagnosis of osteosarcoma can be challenging, given the diverse histologic patterns, limited biopsy samples, lack of tumor-specific molecular alterations, and necessity for radiologic correlation. This review summarizes the key pathologic features of osteosarcoma subtypes with an emphasis on illustrating radiologic, gross macroscopic, and histologic features to help pathologists with classification. In addition, the authors provide an update on recent advances in molecular genetics and summarize pertinent differential diagnoses.

Shown exactly as published on PubMed. Your oncologist is the right person to judge whether these findings apply to your situation.

Publication type

Journal ArticleReview

Source: PubMed, PMID 40716915. Always confirm details with the original publication or your oncologist.