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Review2025

Undifferentiated Small Round Cell Sarcomas of Bone.

Makise N, Yoshida A · Surgical pathology clinics

Sarcoma subtypes

Abstract

Undifferentiated small round cell sarcomas are a heterogeneous group of high-grade sarcomas of uncertain histogenesis. In this review, the key clinicopathological, immunohistochemical, and molecular characteristics of select entities that commonly originate from bones (ie, Ewing sarcoma, BCOR::CCNB3 sarcoma, and EWSR1::NFATC2 sarcomas) are summarized. CIC-rearranged sarcomas are briefly discussed because they rarely arise from bone. Relevant immunohistochemical markers, differential diagnoses, and practical pitfalls are also reviewed.

Shown exactly as published on PubMed. Your oncologist is the right person to judge whether these findings apply to your situation.

Publication type

Journal ArticleReview

Source: PubMed, PMID 40716917. Always confirm details with the original publication or your oncologist.