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International PPB/DICER1 Registry

Sponsor: Children's Hospitals and Clinics of Minnesota · NCT03382158 on ClinicalTrials.gov ↗

Conditions studied

Pleuropulmonary BlastomaSertoli-Leydig Cell TumorDICER1 SyndromeCystic NephromaWilms TumorPineoblastomaRenal SarcomaNodular Hyperplasia of ThyroidNasal Chondromesenchymal HamartomaCiliary Body MedulloepitheliomaNeuroblastomaPituitary CancerEmbryonal RhabdomyosarcomaOvarian SarcomaGynandroblastomaThyroid CarcinomaEmbryonal Rhabdomyosarcoma of Vagina (Diagnosis)Embryonal Rhabdomyosarcoma of Uterus (Diagnosis)Embryonal Rhabdomyosarcoma of Cervix

Where it's running1 site

See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

1. Known or suspected PPB or related thoracic tumor
2. Known or suspected sex-cord stromal tumor including Sertoli-Leydig cell tumor and gynandroblastoma (males or females)
3. Other known or suspected DICER1-related condition including ovarian sarcoma, cystic nephroma, renal sarcoma, pineoblastoma, pituitary blastoma, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma and others
4. Individuals with known or suspected DICER1 pathogenic variation regardless of whether they have an established DICER1-associated condition
5. Informed consent by patient/ or parent/guardian (also, where appropriate: assent and HIPAA consent)

Exclusion criteria:

Absence of appropriate consent for Registry participation

Updated 2025-01-30 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.