← All sarcoma trials
Recruiting nowPhase 3Up to 50 Years

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Sponsor: Children's Oncology Group · NCT05235165 on ClinicalTrials.gov ↗

Bring this to your care team →

Conditions studied

Metastatic Malignant Neoplasm in the LungMetastatic OsteosarcomaOsteosarcoma

What it tests

  • Biospecimen Collectionprocedure
  • Computed Tomographyprocedure
  • Questionnaire Administrationother
  • Thoracoscopyprocedure
  • Thoracotomyprocedure

Where it's running232 sites

  • Children's Hospital of Alabama

    Birmingham, Alabama 35233

    Recruiting now

  • Providence Alaska Medical Center

    Anchorage, Alaska 99508

    Recruiting now

  • Kingman Regional Medical Center

    Kingman, Arizona 86401

    Recruiting now

  • Banner Children's at Desert

    Mesa, Arizona 85202

    Recruiting now
    • Site Public Contact(contact)480-412-3100
    • Joseph C. Torkildson(principal investigator)

  • Phoenix Childrens Hospital

    Phoenix, Arizona 85016

    Recruiting now
    • Site Public Contact(contact)602-546-0920
    • Alok K. Kothari(principal investigator)

  • Banner University Medical Center - Tucson

    Tucson, Arizona 85719

    Recruiting now
    • Site Public Contact(contact)[email protected]
    • Michelina de la Maza(principal investigator)

  • Arkansas Children's Hospital

    Little Rock, Arkansas 72202-3591

    Recruiting now
    • Site Public Contact(contact)501-364-7373
    • Michael W. Bishop(principal investigator)

  • Kaiser Permanente-Anaheim

    Anaheim, California 92806

    Recruiting now

  • PCR Oncology

    Arroyo Grande, California 93420

    Recruiting now

  • Kaiser Permanente-Bellflower

    Bellflower, California 90706

    Recruiting now

  • Kaiser Permanente Downey Medical Center

    Downey, California 90242

    Recruiting now
    • Site Public Contact(contact)626-564-3455
    • Robert M. Cooper(principal investigator)

  • Kaiser Permanente-Fontana

    Fontana, California 92335

    Recruiting now

  • Loma Linda University Medical Center

    Loma Linda, California 92354

    Recruiting now
    • Site Public Contact(contact)909-558-4050
    • Albert Kheradpour(principal investigator)

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California 90806

    Recruiting now
    • Site Public Contact(contact)562-933-5600
    • Jacqueline N. Casillas(principal investigator)

  • Children's Hospital Los Angeles

    Los Angeles, California 90027

    Recruiting now
    • Site Public Contact(contact)323-361-4110
    • Fariba Navid(principal investigator)

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California 90027

    Recruiting now

  • Cedars-Sinai Medical Center

    Los Angeles, California 90048

    Recruiting now

  • Valley Children's Hospital

    Madera, California 93636

    Recruiting now

  • Kaiser Permanente-Oakland

    Oakland, California 94611

    Recruiting now

  • Children's Hospital of Orange County

    Orange, California 92868

    Recruiting now

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California 94304

    Recruiting now

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California 95817

    Recruiting now
    • Site Public Contact(contact)916-734-3089
    • Marcio H. Malogolowkin(principal investigator)

  • Kaiser Permanente-San Diego Zion

    San Diego, California 92120

    Recruiting now

  • Rady Children's Hospital - San Diego

    San Diego, California 92123

    Recruiting now
    • Site Public Contact(contact)858-966-5934
    • William D. Roberts(principal investigator)

  • UCSF Medical Center-Mission Bay

    San Francisco, California 94158

    Recruiting now

  • Children's Hospital Colorado

    Aurora, Colorado 80045

    Recruiting now

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado 80218

    Recruiting now

  • Connecticut Children's Medical Center

    Hartford, Connecticut 06106

    Recruiting now
    • Site Public Contact(contact)860-545-9981
    • Michael S. Isakoff(principal investigator)

  • Smilow Cancer Center/Yale-New Haven Hospital

    New Haven, Connecticut 06510

    Recruiting now

  • Yale University

    New Haven, Connecticut 06520

    Recruiting now

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware 19803

    Recruiting now

  • Children's National Medical Center

    Washington D.C., District of Columbia 20010

    Recruiting now

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida 33908

    Recruiting now

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida 32610

    Active, not recruiting

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida 32207

    Recruiting now

  • Nicklaus Children's Hospital

    Miami, Florida 33155

    Recruiting now
    • Site Public Contact(contact)888-624-2778
    • Maggie E. Fader(principal investigator)

  • Arnold Palmer Hospital for Children

    Orlando, Florida 32806

    Recruiting now

  • Nemours Children's Hospital

    Orlando, Florida 32827

    Recruiting now

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida 33701

    Recruiting now

  • Tampa General Hospital

    Tampa, Florida 33606

    Recruiting now

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida 33607

    Recruiting now

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia 30329

    Recruiting now

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826

    Recruiting now
    • Site Public Contact(contact)808-983-6090
    • Wade T. Kyono(principal investigator)

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho 83712

    Recruiting now

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois 60611

    Recruiting now
    • Site Public Contact(contact)773-880-4562
    • Jennifer L. Reichek(principal investigator)

  • University of Illinois

    Chicago, Illinois 60612

    Recruiting now
    • Site Public Contact(contact)312-355-3046
    • Dipti S. Dighe(principal investigator)

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois 60637

    Recruiting now

  • Loyola University Medical Center

    Maywood, Illinois 60153

    Recruiting now
    • Site Public Contact(contact)708-226-4357
    • Eugene Suh(principal investigator)

  • Saint Jude Midwest Affiliate

    Peoria, Illinois 61637

    Recruiting now
    • Site Public Contact(contact)888-226-4343
    • Prerna Kumar(principal investigator)

  • Northwestern Medicine Central DuPage Hospital

    Winfield, Illinois 60190

    Recruiting now

  • Riley Hospital for Children

    Indianapolis, Indiana 46202

    Recruiting now
    • Site Public Contact(contact)800-248-1199
    • Sandeep Batra(principal investigator)

  • Blank Children's Hospital

    Des Moines, Iowa 50309

    Recruiting now

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa 52242

    Recruiting now
    • Site Public Contact(contact)800-237-1225
    • Andrew P. Groves(principal investigator)

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky 40536

    Recruiting now
    • Site Public Contact(contact)859-257-3379
    • James T. Badgett(principal investigator)

  • Norton Children's Hospital

    Louisville, Kentucky 40202

    Recruiting now

  • Children's Hospital New Orleans

    New Orleans, Louisiana 70118

    Recruiting now
    • Site Public Contact(contact)504-894-5377
    • Maria C. Velez-Yanguas(principal investigator)

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana 70121

    Recruiting now

  • Eastern Maine Medical Center

    Bangor, Maine 04401

    Recruiting now
    • Site Public Contact(contact)207-973-4274
    • Daniel L. Callaway(principal investigator)

  • Maine Children's Cancer Program

    Scarborough, Maine 04074

    Recruiting now

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland 21201

    Recruiting now
    • Site Public Contact(contact)800-888-8823
    • Teresa A. York(principal investigator)

  • Sinai Hospital of Baltimore

    Baltimore, Maryland 21215

    Recruiting now
    • Site Public Contact(contact)410-601-9083
    • Jason M. Fixler(principal investigator)

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland 21287

    Recruiting now

  • Walter Reed National Military Medical Center

    Bethesda, Maryland 20889-5600

    Recruiting now
    • Site Public Contact(contact)301-319-2100
    • Allen I. Stering(principal investigator)

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts 02114

    Recruiting now
    • Site Public Contact(contact)877-726-5130
    • Danielle B. Cameron(principal investigator)

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215

    Recruiting now
    • Site Public Contact(contact)877-442-3324
    • Katherine A. Janeway(principal investigator)

  • C S Mott Children's Hospital

    Ann Arbor, Michigan 48109

    Recruiting now
    • Site Public Contact(contact)800-865-1125
    • Rama Jasty(principal investigator)

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan 48109

    Recruiting now

  • Bronson Battle Creek

    Battle Creek, Michigan 49017

    Recruiting now

  • Children's Hospital of Michigan

    Detroit, Michigan 48201

    Recruiting now

  • Michigan State University

    East Lansing, Michigan 48823

    Suspended

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan 49503

    Recruiting now

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan 49503

    Recruiting now

  • Trinity Health Grand Rapids Hospital

    Grand Rapids, Michigan 49503

    Recruiting now

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007

    Recruiting now

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007

    Recruiting now

  • Beacon Kalamazoo Cancer Center

    Kalamazoo, Michigan 49009

    Recruiting now
    • Site Public Contact(contact)574-647-7370
    • Kathleen Y. Butler(principal investigator)

  • Beacon Kalamazoo

    Kalamazoo, Michigan 49048

    Recruiting now
    • Site Public Contact(contact)574-647-7370
    • Kathleen Y. Butler(principal investigator)

  • Trinity Health Muskegon Hospital

    Muskegon, Michigan 49444

    Recruiting now

  • Corewell Health Lakeland Hospitals - Niles Hospital

    Niles, Michigan 49120

    Recruiting now
    • Site Public Contact(contact)616-391-1230
    • Kathleen Y. Butler(principal investigator)

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    Norton Shores, Michigan 49444

    Recruiting now

  • Corewell Health Reed City Hospital

    Reed City, Michigan 49677

    Recruiting now

  • Corewell Health Children's

    Royal Oak, Michigan 48073

    Recruiting now
    • Site Public Contact(contact)248-551-7695
    • Marie V. Nelson(principal investigator)

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    Saint Joseph, Michigan 49085

    Recruiting now

  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital

    Saint Joseph, Michigan 49085

    Recruiting now

  • Munson Medical Center

    Traverse City, Michigan 49684

    Recruiting now

  • University of Michigan Health - West

    Wyoming, Michigan 49519

    Recruiting now

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota 55404

    Recruiting now

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota 55455

    Recruiting now
    • Site Public Contact(contact)612-624-2620
    • Robin L. Williams(principal investigator)

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Stephanie F. Polites(principal investigator)

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216

    Recruiting now
    • Site Public Contact(contact)601-815-6700
    • Betty L. Herrington(principal investigator)

  • University of Missouri Children's Hospital

    Columbia, Missouri 65212

    Recruiting now

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri 64108

    Recruiting now

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri 63104

    Recruiting now
    • Site Public Contact(contact)314-268-4000
    • William S. Ferguson(principal investigator)

  • Washington University School of Medicine

    St Louis, Missouri 63110

    Recruiting now

  • Mercy Hospital Saint Louis

    St Louis, Missouri 63141

    Recruiting now
    • Site Public Contact(contact)314-251-7066
    • Robin D. Hanson(principal investigator)

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska 68114

    Recruiting now
    • Site Public Contact(contact)402-955-3949
    • Jill C. Beck(principal investigator)

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198

    Recruiting now

  • Carson Tahoe Regional Medical Center

    Carson City, Nevada 89703

    Recruiting now

  • Comprehensive Cancer Centers of Nevada - Henderson

    Henderson, Nevada 89052

    Recruiting now

  • Comprehensive Cancer Centers of Nevada-Horizon Ridge

    Henderson, Nevada 89052

    Recruiting now

  • Las Vegas Cancer Center-Henderson

    Henderson, Nevada 89052

    Suspended

  • Comprehensive Cancer Centers of Nevada-Southeast Henderson

    Henderson, Nevada 89074

    Recruiting now

  • Las Vegas Urology - Green Valley

    Henderson, Nevada 89074

    Recruiting now

  • Las Vegas Urology - Pebble

    Henderson, Nevada 89074

    Recruiting now

  • Oncology Las Vegas - Henderson

    Henderson, Nevada 89074

    Recruiting now

  • Urology Specialists of Nevada - Green Valley

    Henderson, Nevada 89074

    Recruiting now

  • Las Vegas Urology - Pecos

    Las Vegas, Nevada 89074

    Recruiting now

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada 89102

    Recruiting now

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada 89102

    Recruiting now

  • Hope Cancer Care of Nevada

    Las Vegas, Nevada 89103

    Recruiting now

  • Radiation Oncology Centers of Nevada Central

    Las Vegas, Nevada 89106

    Recruiting now

  • Urology Specialists of Nevada - Central

    Las Vegas, Nevada 89106

    Recruiting now

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada 89109

    Recruiting now

  • Las Vegas Urology - Sunset

    Las Vegas, Nevada 89113

    Recruiting now

  • Urology Specialists of Nevada - Southwest

    Las Vegas, Nevada 89113

    Recruiting now

  • Radiation Oncology Centers of Nevada Southeast

    Las Vegas, Nevada 89119

    Recruiting now

  • Ann M Wierman MD LTD

    Las Vegas, Nevada 89128

    Suspended

  • Comprehensive Cancer Centers of Nevada - Northwest

    Las Vegas, Nevada 89128

    Recruiting now

  • Las Vegas Urology - Cathedral Rock

    Las Vegas, Nevada 89128

    Recruiting now

  • Las Vegas Urology - Smoke Ranch

    Las Vegas, Nevada 89128

    Recruiting now

  • Oncology Las Vegas - Tenaya

    Las Vegas, Nevada 89128

    Recruiting now

  • OptumCare Cancer Care at MountainView

    Las Vegas, Nevada 89128

    Recruiting now

  • Urology Specialists of Nevada - Northwest

    Las Vegas, Nevada 89128

    Recruiting now

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada 89135

    Recruiting now

  • Comprehensive Cancer Centers of Nevada - Town Center

    Las Vegas, Nevada 89144

    Recruiting now

  • Comprehensive Cancer Centers of Nevada-Summerlin

    Las Vegas, Nevada 89144

    Recruiting now

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada 89144

    Recruiting now

  • Las Vegas Cancer Center-Medical Center

    Las Vegas, Nevada 89148-2405

    Suspended

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada 89148

    Recruiting now

  • Comprehensive Cancer Centers of Nevada - Central Valley

    Las Vegas, Nevada 89169

    Recruiting now

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada 89183

    Recruiting now

  • Hope Cancer Care of Nevada-Pahrump

    Pahrump, Nevada 89048

    Recruiting now

  • Renown Regional Medical Center

    Reno, Nevada 89502

    Recruiting now

  • Saint Mary's Regional Medical Center

    Reno, Nevada 89503

    Recruiting now

  • Radiation Oncology Associates

    Reno, Nevada 89509

    Recruiting now

  • Northern Nevada Radiation Oncology

    Reno, Nevada 89521

    Suspended

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire 03756

    Recruiting now

  • Hackensack University Medical Center

    Hackensack, New Jersey 07601

    Recruiting now
    • Site Public Contact(contact)551-996-2897
    • Katharine Offer(principal investigator)

  • Morristown Medical Center

    Morristown, New Jersey 07960

    Recruiting now
    • Site Public Contact(contact)973-971-5900
    • Kathryn L. Laurie(principal investigator)

  • Saint Peter's University Hospital

    New Brunswick, New Jersey 08901

    Recruiting now

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey 08903

    Recruiting now
    • Site Public Contact(contact)732-235-8675
    • Scott Moerdler(principal investigator)

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey 07503

    Recruiting now

  • Presbyterian Hospital

    Albuquerque, New Mexico 87106

    Recruiting now

  • Albany Medical Center

    Albany, New York 12208

    Recruiting now
    • Site Public Contact(contact)518-262-5513
    • Lauren R. Weintraub(principal investigator)

  • Maimonides Medical Center

    Brooklyn, New York 11219

    Recruiting now
    • Site Public Contact(contact)718-765-2500
    • Mahmut Y. Celiker(principal investigator)

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York 11040

    Recruiting now
    • Site Public Contact(contact)718-470-3460
    • Carolyn F. Levy(principal investigator)

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York 10016

    Recruiting now

  • Mount Sinai Hospital

    New York, New York 10029

    Recruiting now

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York 10032

    Recruiting now

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Damon R. Reed(principal investigator)

  • Stony Brook University Medical Center

    Stony Brook, New York 11794

    Recruiting now
    • Site Public Contact(contact)800-862-2215
    • Laura E. Hogan(principal investigator)

  • State University of New York Upstate Medical University

    Syracuse, New York 13210

    Recruiting now
    • Site Public Contact(contact)315-464-5476
    • Melanie A. Comito(principal investigator)

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York 10461

    Recruiting now

  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York 10461

    Recruiting now

  • Children's Hospital at Montefiore

    The Bronx, New York 10467

    Recruiting now

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York 10467

    Recruiting now

  • New York Medical College

    Valhalla, New York 10595

    Recruiting now
    • Site Public Contact(contact)914-594-3794
    • Jessica C. Hochberg(principal investigator)

  • Westchester Medical Center

    Valhalla, New York 10595

    Recruiting now

  • Mission Hospital

    Asheville, North Carolina 28801

    Recruiting now

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina 27599

    Recruiting now

  • Duke University Medical Center

    Durham, North Carolina 27710

    Recruiting now
    • Site Public Contact(contact)888-275-3853
    • Jessica M. Sun(principal investigator)

  • East Carolina University

    Greenville, North Carolina 27834

    Recruiting now

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina 27157

    Recruiting now
    • Site Public Contact(contact)336-713-6771
    • Sarah Supples(principal investigator)

  • Sanford Broadway Medical Center

    Fargo, North Dakota 58122

    Recruiting now

  • Children's Hospital Medical Center of Akron

    Akron, Ohio 44308

    Recruiting now
    • Site Public Contact(contact)330-543-3193
    • Erin Wright(principal investigator)

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio 45229

    Recruiting now

  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio 44106

    Recruiting now
    • Site Public Contact(contact)216-844-5437
    • Duncan S. Stearns(principal investigator)

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195

    Recruiting now

  • Nationwide Children's Hospital

    Columbus, Ohio 43205

    Recruiting now

  • Dayton Children's Hospital

    Dayton, Ohio 45404

    Recruiting now
    • Site Public Contact(contact)800-228-4055
    • Jordan M. Wright(principal investigator)

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio 43606

    Recruiting now

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104

    Recruiting now

  • Legacy Emanuel Children's Hospital

    Portland, Oregon 97227

    Recruiting now
    • Site Public Contact(contact)503-413-2560
    • Jason M. Glover(principal investigator)

  • Oregon Health and Science University

    Portland, Oregon 97239

    Recruiting now

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania 18103

    Recruiting now

  • Geisinger Medical Center

    Danville, Pennsylvania 17822

    Recruiting now

  • Penn State Children's Hospital

    Hershey, Pennsylvania 17033

    Recruiting now
    • Site Public Contact(contact)717-531-6012
    • Lisa M. McGregor(principal investigator)

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania 19134

    Recruiting now
    • Site Public Contact(contact)215-427-8991
    • Gregory E. Halligan(principal investigator)

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania 15224

    Recruiting now

  • Rhode Island Hospital

    Providence, Rhode Island 02903

    Recruiting now
    • Site Public Contact(contact)401-444-1488
    • Bradley DeNardo(principal investigator)

  • Medical University of South Carolina

    Charleston, South Carolina 29425

    Recruiting now

  • Prisma Health Richland Hospital

    Columbia, South Carolina 29203

    Recruiting now

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina 29605

    Recruiting now

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota 57117-5134

    Recruiting now

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee 37916

    Recruiting now
    • Site Public Contact(contact)865-541-8266
    • Susan E. Spiller(principal investigator)

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee 38105

    Recruiting now

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee 37203

    Recruiting now
    • Site Public Contact(contact)615-342-1919
    • Clinton M. Carroll(principal investigator)

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee 37232

    Recruiting now
    • Site Public Contact(contact)800-811-8480
    • Scott C. Borinstein(principal investigator)

  • Texas Tech University Health Sciences Center-Amarillo

    Amarillo, Texas 79106

    Recruiting now
    • Site Public Contact(contact)806-354-5411
    • Smita Bhaskaran(principal investigator)

  • Dell Children's Medical Center of Central Texas

    Austin, Texas 78723

    Recruiting now

  • Driscoll Children's Hospital

    Corpus Christi, Texas 78411

    Recruiting now

  • Medical City Dallas Hospital

    Dallas, Texas 75230

    Recruiting now
    • Site Public Contact(contact)972-566-5588
    • Maurizio L. Ghisoli(principal investigator)

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas 75390

    Recruiting now

  • El Paso Children's Hospital

    El Paso, Texas 79905

    Recruiting now

  • Cook Children's Medical Center

    Fort Worth, Texas 76104

    Recruiting now

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas 77030

    Recruiting now

  • M D Anderson Cancer Center

    Houston, Texas 77030

    Recruiting now

  • Children's Hospital of San Antonio

    San Antonio, Texas 78207

    Recruiting now

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas 78229

    Recruiting now

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas 78229

    Recruiting now

  • Primary Children's Hospital

    Salt Lake City, Utah 84113

    Recruiting now
    • Site Public Contact(contact)801-585-5270
    • Matthew Dietz(principal investigator)

  • University of Vermont and State Agricultural College

    Burlington, Vermont 05405

    Active, not recruiting

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908

    Recruiting now

  • Inova Fairfax Hospital

    Falls Church, Virginia 22042

    Recruiting now

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia 23507

    Recruiting now

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia 23235

    Recruiting now

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia 23298

    Recruiting now

  • Carilion Children's

    Roanoke, Virginia 24014

    Recruiting now

  • Overlake Medical Center

    Bellevue, Washington 98004

    Suspended

  • Valley Medical Center

    Renton, Washington 98055

    Recruiting now

  • Seattle Children's Hospital

    Seattle, Washington 98105

    Recruiting now
    • Site Public Contact(contact)866-987-2000
    • Sarah E. Leary(principal investigator)

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington 99204

    Recruiting now

  • Mary Bridge Children's Hospital and Health Center

    Tacoma, Washington 98405

    Recruiting now

  • Madigan Army Medical Center

    Tacoma, Washington 98431

    Recruiting now

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington 98902

    Recruiting now

  • West Virginia University Healthcare

    Morgantown, West Virginia 26506

    Recruiting now

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin 53792

    Recruiting now

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin 54449

    Recruiting now

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin 53226

    Recruiting now
13 international sites

  • The Children's Hospital at Westmead

    Westmead, New South Wales, Australia 2145

    Suspended

  • Royal Children's Hospital

    Parkville, Victoria, Australia 3052

    Suspended

  • Perth Children's Hospital

    Perth, Western Australia, Australia 6009

    Suspended

  • Alberta Children's Hospital

    Calgary, Alberta, Canada T3B 6A8

    Recruiting now

  • University of Alberta Hospital

    Edmonton, Alberta, Canada T6G 2B7

    Recruiting now

  • IWK Health Centre

    Halifax, Nova Scotia, Canada B3K 6R8

    Recruiting now

  • The Montreal Children's Hospital of the MUHC

    Montreal, Quebec, Canada H3H 1P3

    Recruiting now

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, Canada H3T 1C5

    Recruiting now

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, Canada J1H 5N4

    Recruiting now

  • Starship Children's Hospital

    Grafton, Auckland, New Zealand 1145

    Recruiting now
    • Site Public Contact(contact)0800 728 436
    • Mandy PohLui de Silva(principal investigator)

  • Christchurch Hospital

    Christchurch, New Zealand 8011

    Recruiting now
    • Site Public Contact(contact)03 364 0640
    • Tristan Pettit(principal investigator)

  • HIMA San Pablo Oncologic Hospital

    Caguas, Puerto Rico 00726

    Active, not recruiting

  • King Faisal Specialist Hospital and Research Centre

    Riyadh, Saudi Arabia 11211

    Suspended
See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Patients must be \< 50 years at the time of enrollment.
* Patients must have =\< 4 nodules per lung consistent with or suspicious for metastases, with at least one of which being \>= 3 mm and all of which must be =\< 3 cm size.

  * Note: Patient must have eligibility confirmed by rapid central imaging review.
* Lung nodules must be considered resectable by either open thoracotomy or thoracoscopic surgery. Determination of resectability is made by the institutional surgeon.
* Patients must have a histological diagnosis of osteosarcoma.
* Patients must have evidence of metastatic lung disease at the time of initial diagnosis, or at time of 1st recurrence following completion of therapy for initially localized disease.
* Patients with newly diagnosed disease must have completed successful gross tumor resection for their primary tumor or surgical local control of primary tumor must be planned to be performed simultaneously with thoracic surgery.
* Newly diagnosed patients must be receiving or recently completed (within 60 days) systemic therapy considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.
* Patients at time of 1st recurrence must have completed systemic therapy for their initial primary tumor, considered by the treating physician to be standard treatment for newly diagnosed osteosarcoma (eg, cisplatin-doxorubicin or ifosfamide-based drug regimens) at the time of enrollment on this study. Dose and drug modifications for toxicity do not exclude patients from participation.

Exclusion Criteria:

* Patients with unresectable primary tumor.
* Patients with pulmonary metastatic lesions that would require anatomic resection (lobectomy or pneumonectomy) or lesions that are defined as "central" (i.e., central lesion involves or is proximal to segmental bronchi and peripheral is lesion distal to segmental bronchi).
* Patients with chest wall or mediastinal based metastatic lesions, or with significant pleural effusion.
* Patients with disease progression at either the primary or pulmonary metastatic site while on initial therapy. Note: Once the patient has been enrolled on the study, additional computed tomography (CT) scans are not anticipated prior to thoracic surgery. Note: Some variation in nodule size measurements over the course of pre-operative therapy is anticipated and does not qualify for exclusion unless deemed true disease progression by the primary treatment team.
* Patients with evidence of extrapulmonary metastatic disease.
* Patients who received therapeutic pulmonary surgery for lung metastasis prior to enrollment.
* All patients and/or their parents or legal guardians must sign a written informed consent.
* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Updated 2026-05-05 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.