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Recruiting nowPhase 3Up to 21 Years

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

Sponsor: Children's Oncology Group · NCT05304585 on ClinicalTrials.gov ↗

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Conditions studied

Embryonal RhabdomyosarcomaFusion-Negative Alveolar RhabdomyosarcomaSpindle Cell/Sclerosing Rhabdomyosarcoma

What it tests

  • Biopsy Procedureprocedure
  • Bone Scanprocedure
  • Computed Tomographyprocedure
  • Cyclophosphamidedrug
  • Dactinomycinbiological
  • Magnetic Resonance Elastographyprocedure
  • Positron Emission Tomographyprocedure
  • Radiation Therapyradiation
  • Vincristinedrug

Where it's running180 sites

  • Children's Hospital of Alabama

    Birmingham, Alabama 35233

    Recruiting now

  • USA Health Strada Patient Care Center

    Mobile, Alabama 36604

    Recruiting now
    • Site Public Contact(contact)800-388-8721
    • Hamayun Imran(principal investigator)

  • Phoenix Childrens Hospital

    Phoenix, Arizona 85016

    Recruiting now
    • Site Public Contact(contact)602-546-0920
    • Nawal Merjaneh(principal investigator)

  • Arkansas Children's Hospital

    Little Rock, Arkansas 72202-3591

    Recruiting now
    • Site Public Contact(contact)501-364-7373
    • Michael W. Bishop(principal investigator)

  • Kaiser Permanente Downey Medical Center

    Downey, California 90242

    Recruiting now
    • Site Public Contact(contact)626-564-3455
    • Robert M. Cooper(principal investigator)

  • Loma Linda University Medical Center

    Loma Linda, California 92354

    Recruiting now
    • Site Public Contact(contact)909-558-4050
    • Albert Kheradpour(principal investigator)

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California 90806

    Recruiting now
    • Site Public Contact(contact)562-933-5600
    • Jacqueline N. Casillas(principal investigator)

  • Children's Hospital Los Angeles

    Los Angeles, California 90027

    Recruiting now
    • Site Public Contact(contact)323-361-4110
    • Sara Kreimer(principal investigator)

  • Cedars-Sinai Medical Center

    Los Angeles, California 90048

    Recruiting now

  • Mattel Children's Hospital UCLA

    Los Angeles, California 90095

    Recruiting now
    • Site Public Contact(contact)310-825-6708
    • Satiro N. De Oliveira(principal investigator)

  • Valley Children's Hospital

    Madera, California 93636

    Recruiting now

  • UCSF Benioff Children's Hospital Oakland

    Oakland, California 94609

    Recruiting now

  • Kaiser Permanente-Oakland

    Oakland, California 94611

    Recruiting now

  • Children's Hospital of Orange County

    Orange, California 92868

    Recruiting now

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California 94304

    Recruiting now

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California 95817

    Recruiting now
    • Site Public Contact(contact)916-734-3089
    • Marcio H. Malogolowkin(principal investigator)

  • Rady Children's Hospital - San Diego

    San Diego, California 92123

    Recruiting now
    • Site Public Contact(contact)858-966-5934
    • William D. Roberts(principal investigator)

  • Naval Medical Center -San Diego

    San Diego, California 92134

    Recruiting now
    • Site Public Contact(contact)619-532-8712
    • Yoko T. Udaka(principal investigator)

  • UCSF Medical Center-Mission Bay

    San Francisco, California 94158

    Recruiting now

  • Children's Hospital Colorado

    Aurora, Colorado 80045

    Recruiting now

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado 80218

    Recruiting now

  • Connecticut Children's Medical Center

    Hartford, Connecticut 06106

    Recruiting now
    • Site Public Contact(contact)860-545-9981
    • Michael S. Isakoff(principal investigator)

  • Yale University

    New Haven, Connecticut 06520

    Recruiting now

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware 19803

    Recruiting now

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia 20007

    Recruiting now
    • Site Public Contact(contact)202-444-2223
    • Caileigh Pudela(principal investigator)

  • Children's National Medical Center

    Washington D.C., District of Columbia 20010

    Recruiting now

  • Broward Health Medical Center

    Fort Lauderdale, Florida 33316

    Recruiting now

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida 33908

    Recruiting now

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida 32610

    Recruiting now

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida 33021

    Recruiting now

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida 32207

    Recruiting now

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida 33136

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Aditi Dhir(principal investigator)

  • Nicklaus Children's Hospital

    Miami, Florida 33155

    Recruiting now
    • Site Public Contact(contact)888-624-2778
    • Maggie E. Fader(principal investigator)

  • AdventHealth Orlando

    Orlando, Florida 32803

    Recruiting now

  • Arnold Palmer Hospital for Children

    Orlando, Florida 32806

    Recruiting now

  • Nemours Children's Hospital

    Orlando, Florida 32827

    Recruiting now

  • Nemours Children's Clinic - Pensacola

    Pensacola, Florida 32504

    Recruiting now

  • Sacred Heart Hospital

    Pensacola, Florida 32504

    Suspended

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida 33701

    Recruiting now

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida 33607

    Recruiting now

  • Saint Mary's Medical Center

    West Palm Beach, Florida 33407

    Recruiting now
    • Site Public Contact(contact)561-822-4745
    • Matthew D. Ramirez(principal investigator)

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia 30329

    Recruiting now

  • Atrium Health Navicent

    Macon, Georgia 31201

    Recruiting now

  • Memorial Health University Medical Center

    Savannah, Georgia 31404

    Recruiting now

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826

    Recruiting now
    • Site Public Contact(contact)808-983-6090
    • Wade T. Kyono(principal investigator)

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho 83712

    Recruiting now

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois 60611

    Recruiting now
    • Site Public Contact(contact)773-880-4562
    • Jennifer L. Reichek(principal investigator)

  • University of Illinois

    Chicago, Illinois 60612

    Suspended

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois 60637

    Recruiting now

  • Loyola University Medical Center

    Maywood, Illinois 60153

    Recruiting now
    • Site Public Contact(contact)708-226-4357
    • Eugene Suh(principal investigator)

  • Advocate Children's Hospital-Oak Lawn

    Oak Lawn, Illinois 60453

    Recruiting now
    • Site Public Contact(contact)847-723-7570
    • Rebecca E. McFall(principal investigator)

  • Advocate Children's Hospital-Park Ridge

    Park Ridge, Illinois 60068

    Recruiting now

  • Saint Jude Midwest Affiliate

    Peoria, Illinois 61637

    Recruiting now
    • Site Public Contact(contact)888-226-4343
    • Prerna Kumar(principal investigator)

  • Southern Illinois University School of Medicine

    Springfield, Illinois 62702

    Recruiting now
    • Site Public Contact(contact)217-545-7929
    • Gregory P. Brandt(principal investigator)

  • Northwestern Medicine Central DuPage Hospital

    Winfield, Illinois 60190

    Recruiting now

  • Riley Hospital for Children

    Indianapolis, Indiana 46202

    Recruiting now
    • Site Public Contact(contact)800-248-1199
    • Sandeep Batra(principal investigator)

  • Ascension Saint Vincent Indianapolis Hospital

    Indianapolis, Indiana 46260

    Recruiting now

  • Blank Children's Hospital

    Des Moines, Iowa 50309

    Recruiting now

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa 52242

    Recruiting now
    • Site Public Contact(contact)800-237-1225
    • Andrew P. Groves(principal investigator)

  • Wesley Medical Center

    Wichita, Kansas 67214

    Recruiting now

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky 40536

    Recruiting now
    • Site Public Contact(contact)859-257-3379
    • James T. Badgett(principal investigator)

  • Norton Children's Hospital

    Louisville, Kentucky 40202

    Recruiting now

  • Children's Hospital New Orleans

    New Orleans, Louisiana 70118

    Recruiting now
    • Site Public Contact(contact)504-894-5377
    • Maria C. Velez-Yanguas(principal investigator)

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana 70121

    Recruiting now

  • Maine Children's Cancer Program

    Scarborough, Maine 04074

    Recruiting now

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland 21201

    Recruiting now
    • Site Public Contact(contact)800-888-8823
    • Teresa A. York(principal investigator)

  • Sinai Hospital of Baltimore

    Baltimore, Maryland 21215

    Recruiting now
    • Site Public Contact(contact)410-601-9083
    • Jason M. Fixler(principal investigator)

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland 21287

    Recruiting now

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts 02114

    Recruiting now
    • Site Public Contact(contact)877-726-5130
    • Alison M. Friedmann(principal investigator)

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215

    Recruiting now
    • Site Public Contact(contact)877-442-3324
    • Natalie B. Collins(principal investigator)

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts 01655

    Recruiting now

  • C S Mott Children's Hospital

    Ann Arbor, Michigan 48109

    Recruiting now
    • Site Public Contact(contact)800-865-1125
    • Rama Jasty(principal investigator)

  • Children's Hospital of Michigan

    Detroit, Michigan 48201

    Recruiting now

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan 49503

    Recruiting now

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007

    Recruiting now

  • Corewell Health Children's

    Royal Oak, Michigan 48073

    Recruiting now
    • Site Public Contact(contact)248-551-7695
    • Marie V. Nelson(principal investigator)

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota 55404

    Recruiting now

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota 55455

    Recruiting now
    • Site Public Contact(contact)612-624-2620
    • Robin L. Williams(principal investigator)

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Wendy Allen-Rhoades(principal investigator)

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216

    Recruiting now
    • Site Public Contact(contact)601-815-6700
    • Betty L. Herrington(principal investigator)

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri 64108

    Recruiting now

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri 63104

    Recruiting now
    • Site Public Contact(contact)314-268-4000
    • William S. Ferguson(principal investigator)

  • Washington University School of Medicine

    St Louis, Missouri 63110

    Recruiting now

  • Mercy Hospital Saint Louis

    St Louis, Missouri 63141

    Recruiting now
    • Site Public Contact(contact)314-251-7066
    • Robin D. Hanson(principal investigator)

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska 68114

    Recruiting now
    • Site Public Contact(contact)402-955-3949
    • Jill C. Beck(principal investigator)

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198

    Recruiting now

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada 89135

    Recruiting now

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada 89144

    Recruiting now

  • Renown Regional Medical Center

    Reno, Nevada 89502

    Recruiting now

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire 03756

    Recruiting now

  • Hackensack University Medical Center

    Hackensack, New Jersey 07601

    Recruiting now
    • Site Public Contact(contact)551-996-2897
    • Katharine Offer(principal investigator)

  • Morristown Medical Center

    Morristown, New Jersey 07960

    Recruiting now
    • Site Public Contact(contact)973-971-5900
    • Kathryn L. Laurie(principal investigator)

  • Jersey Shore Medical Center

    Neptune City, New Jersey 07753

    Recruiting now
    • Site Public Contact(contact)732-776-4240
    • Katharine Offer(principal investigator)

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey 08903

    Recruiting now
    • Site Public Contact(contact)732-235-8675
    • Scott Moerdler(principal investigator)

  • Newark Beth Israel Medical Center

    Newark, New Jersey 07112

    Recruiting now

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87106

    Recruiting now

  • Albany Medical Center

    Albany, New York 12208

    Recruiting now
    • Site Public Contact(contact)518-262-5513
    • Lauren R. Weintraub(principal investigator)

  • Roswell Park Cancer Institute

    Buffalo, New York 14263

    Recruiting now

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York 11040

    Recruiting now
    • Site Public Contact(contact)718-470-3460
    • Carolyn F. Levy(principal investigator)

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York 10016

    Recruiting now

  • Mount Sinai Hospital

    New York, New York 10029

    Recruiting now

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York 10032

    Recruiting now

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Leonard H. Wexler(principal investigator)

  • University of Rochester

    Rochester, New York 14642

    Recruiting now
    • Site Public Contact(contact)585-275-5830
    • Rafi R. Kazi(principal investigator)

  • State University of New York Upstate Medical University

    Syracuse, New York 13210

    Recruiting now
    • Site Public Contact(contact)315-464-5476
    • Melanie A. Comito(principal investigator)

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York 10467

    Recruiting now

  • New York Medical College

    Valhalla, New York 10595

    Recruiting now
    • Site Public Contact(contact)914-594-3794
    • Jessica C. Hochberg(principal investigator)

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina 27599

    Recruiting now

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina 28203

    Recruiting now
    • Site Public Contact(contact)800-804-9376
    • Joel A. Kaplan(principal investigator)

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina 28204

    Recruiting now

  • Duke University Medical Center

    Durham, North Carolina 27710

    Recruiting now
    • Site Public Contact(contact)888-275-3853
    • Jessica M. Sun(principal investigator)

  • East Carolina University

    Greenville, North Carolina 27834

    Recruiting now

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina 27157

    Recruiting now
    • Site Public Contact(contact)336-713-6771
    • Sarah Supples(principal investigator)

  • Sanford Broadway Medical Center

    Fargo, North Dakota 58122

    Recruiting now

  • Children's Hospital Medical Center of Akron

    Akron, Ohio 44308

    Recruiting now
    • Site Public Contact(contact)330-543-3193
    • Erin Wright(principal investigator)

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio 45229

    Recruiting now

  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio 44106

    Recruiting now
    • Site Public Contact(contact)216-844-5437
    • Duncan S. Stearns(principal investigator)

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195

    Recruiting now

  • Nationwide Children's Hospital

    Columbus, Ohio 43205

    Recruiting now

  • Dayton Children's Hospital

    Dayton, Ohio 45404

    Recruiting now
    • Site Public Contact(contact)800-228-4055
    • Jordan M. Wright(principal investigator)

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio 43606

    Recruiting now

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104

    Recruiting now

  • Oregon Health and Science University

    Portland, Oregon 97239

    Recruiting now

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania 18103

    Recruiting now

  • Geisinger Medical Center

    Danville, Pennsylvania 17822

    Recruiting now

  • Penn State Children's Hospital

    Hershey, Pennsylvania 17033

    Recruiting now
    • Site Public Contact(contact)717-531-6012
    • Lisa M. McGregor(principal investigator)

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania 19104

    Recruiting now

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania 19134

    Recruiting now
    • Site Public Contact(contact)215-427-8991
    • Gregory E. Halligan(principal investigator)

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania 15224

    Recruiting now

  • Rhode Island Hospital

    Providence, Rhode Island 02903

    Recruiting now
    • Site Public Contact(contact)401-444-1488
    • Bradley DeNardo(principal investigator)

  • Prisma Health Richland Hospital

    Columbia, South Carolina 29203

    Recruiting now

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina 29605

    Recruiting now

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota 57117-5134

    Recruiting now

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee 37916

    Recruiting now
    • Site Public Contact(contact)865-541-8266
    • Susan E. Spiller(principal investigator)

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee 38105

    Recruiting now

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee 37203

    Recruiting now
    • Site Public Contact(contact)615-342-1919
    • Clinton M. Carroll(principal investigator)

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee 37232

    Recruiting now
    • Site Public Contact(contact)800-811-8480
    • Scott C. Borinstein(principal investigator)

  • Dell Children's Medical Center of Central Texas

    Austin, Texas 78723

    Recruiting now

  • Driscoll Children's Hospital

    Corpus Christi, Texas 78411

    Recruiting now

  • Medical City Dallas Hospital

    Dallas, Texas 75230

    Recruiting now
    • Site Public Contact(contact)972-566-5588
    • Maurizio L. Ghisoli(principal investigator)

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas 75390

    Recruiting now

  • El Paso Children's Hospital

    El Paso, Texas 79905

    Recruiting now

  • Cook Children's Medical Center

    Fort Worth, Texas 76104

    Recruiting now

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas 77030

    Recruiting now

  • M D Anderson Cancer Center

    Houston, Texas 77030

    Recruiting now

  • Covenant Children's Hospital

    Lubbock, Texas 79410

    Recruiting now

  • UMC Cancer Center / UMC Health System

    Lubbock, Texas 79415

    Recruiting now
    • Site Public Contact(contact)806-775-8590
    • Erin K. Barr(principal investigator)

  • Children's Hospital of San Antonio

    San Antonio, Texas 78207

    Recruiting now

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas 78229

    Recruiting now

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas 78229

    Recruiting now

  • Scott and White Memorial Hospital

    Temple, Texas 76508

    Recruiting now
    • Site Public Contact(contact)254-724-5407
    • Nicholas W. McGregor(principal investigator)

  • Primary Children's Hospital

    Salt Lake City, Utah 84113

    Recruiting now
    • Site Public Contact(contact)801-585-5270
    • Matthew Dietz(principal investigator)

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908

    Recruiting now

  • Inova Fairfax Hospital

    Falls Church, Virginia 22042

    Recruiting now

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia 23507

    Recruiting now

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia 23298

    Recruiting now

  • Carilion Children's

    Roanoke, Virginia 24014

    Recruiting now

  • Seattle Children's Hospital

    Seattle, Washington 98105

    Recruiting now
    • Site Public Contact(contact)866-987-2000
    • Sarah E. Leary(principal investigator)

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington 99204

    Recruiting now

  • Mary Bridge Children's Hospital and Health Center

    Tacoma, Washington 98405

    Recruiting now

  • Madigan Army Medical Center

    Tacoma, Washington 98431

    Recruiting now

  • West Virginia University Charleston Division

    Charleston, West Virginia 25304

    Recruiting now
    • Site Public Contact(contact)304-388-9944
    • Mohamad H. Badawi(principal investigator)

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin 53792

    Recruiting now

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin 54449

    Recruiting now

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin 53226

    Recruiting now
15 international sites

  • Sydney Children's Hospital

    Randwick, New South Wales, Australia 2031

    Recruiting now
    • Site Public Contact(contact)(02) 9382-1721
    • Draga Barbaric(principal investigator)

  • The Children's Hospital at Westmead

    Westmead, New South Wales, Australia 2145

    Recruiting now
    • Site Public Contact(contact)61-2-9845 1400
    • Bhavna Padhye(principal investigator)

  • Perth Children's Hospital

    Perth, Western Australia, Australia 6009

    Recruiting now
    • Site Public Contact(contact)[email protected]
    • Marianne B. Phillips(principal investigator)

  • Alberta Children's Hospital

    Calgary, Alberta, Canada T3B 6A8

    Recruiting now

  • University of Alberta Hospital

    Edmonton, Alberta, Canada T6G 2B7

    Recruiting now

  • British Columbia Children's Hospital

    Vancouver, British Columbia, Canada V6H 3V4

    Recruiting now
    • Site Public Contact(contact)604-875-2345
    • Rebecca J. Deyell(principal investigator)

  • CancerCare Manitoba

    Winnipeg, Manitoba, Canada R3E 0V9

    Recruiting now

  • IWK Health Centre

    Halifax, Nova Scotia, Canada B3K 6R8

    Recruiting now

  • Hospital for Sick Children

    Toronto, Ontario, Canada M5G 1X8

    Recruiting now

  • The Montreal Children's Hospital of the MUHC

    Montreal, Quebec, Canada H3H 1P3

    Recruiting now

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, Canada H3T 1C5

    Recruiting now

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, Canada J1H 5N4

    Recruiting now

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    Québec, Canada G1V 4G2

    Recruiting now

  • Starship Children's Hospital

    Grafton, Auckland, New Zealand 1145

    Recruiting now
    • Site Public Contact(contact)0800 728 436
    • Mandy PohLui de Silva(principal investigator)

  • Christchurch Hospital

    Christchurch, New Zealand 8011

    Recruiting now
    • Site Public Contact(contact)03 364 0640
    • Tristan Pettit(principal investigator)
See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* All patients must be enrolled on APEC14B1 (NCT02402244) and consented to the Molecular Characterization Initiative (Part A) prior to enrollment and treatment on ARST2032 (this trial).
* Patients must be =\< 21 years at the time of enrollment.
* Patients must have newly diagnosed embryonal rhabdomyosarcoma (ERMS), spindle cell/sclerosing RMS, or FOXO1 fusion negative alveolar rhabdomyosarcoma (ARMS) (institutional FOXO1 fusion results are acceptable). RMS types included under ERMS include those classified in the 1995 International Classification of Rhabdomyosarcoma (ICR) as ERMS (classic, spindle cell, and botryoid variants), which are reclassified in the 2020 World Health Organization (WHO) classification as ERMS (classic, dense and botryoid variants) and spindle cell/sclerosing RMS (encompassing the historical spindle cell ERMS variant and the newly recognized sclerosing RMS variant). Enrollment in APEC14B1 is required for all patients.

  * All patients will be evaluated for stage and clinical group. Note that clinical group designation assigned at the time of enrollment on study remains unchanged regardless of any second-look operation that may be performed.

    * Patients will be eligible for the very low-risk stratum (Regimen VA) if they have Stage 1, CG I disease.
    * Patients will be eligible for the low-risk stratum (Regimen VAC/VA) if they have Stage 1, CG II disease, Stage 2, CG I or II disease, or Stage 1, CG III (orbit only) disease.
  * Paratesticular Tumors: Staging ipsilateral retroperitoneal lymph node sampling (SIRLNS) is required for all patients \>= 10 years of age with paratesticular tumors who do not have gross nodal involvement on imaging.
  * Extremity Tumors: Regional lymph node sampling is required for histologic evaluation in patients with extremity tumors.
  * Clinically or radiographically enlarged nodes must be sampled for histologic evaluation.
* Patients must have a Lansky (for patients =\< 16 years of age) or Karnofsky (for patients \> 16 years of age) performance status score of \>= 50. Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing performance score.
* Peripheral absolute neutrophil count (ANC) \>= 750/uL (within 7 days prior to enrollment).
* Platelet count \>= 75,000/uL (transfusion independent) (within 7 days prior to enrollment).
* Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 or a serum creatinine (within 7 days prior to enrollment) based on age/gender as follows:

  * Age: 1 month to \< 6 months; Maximum serum creatinine (mg/dL): 0.4 (male) : 0.4 (female)
  * Age: 6 months to \< 1 year; Maximum serum creatinine (mg/dL): 0.5 (male) : 0.5 (female)
  * Age: 1 to \< 2 years; Maximum serum creatinine (mg/dL): 0.6 (male) : 0.6 (female)
  * Age: 2 to \< 6 years; Maximum serum creatinine (mg/dL): 0.8 (male) : 0.8 (female)
  * Age: 6 to \< 10 years; Maximum serum creatinine (mg/dL): 1 (male) : 1 (female)
  * Age: 10 to \< 13 years; Maximum serum creatinine (mg/dL): 1.2 (male) : 1.2 (female)
  * Age: 13 to \< 16 years; Maximum serum creatinine (mg/dL): 1.5 (male) : 1.4 (female)
  * Age \>= 16 years; Maximum serum creatinine (mg/dL): 1.7 (male) : 1.4 (female)
* Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment), and

  * If there is evidence of biliary obstruction by the tumor, then the total bilirubin must be \< 3 x ULN for age.
  * Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U/L.
* Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) =\< 135 U/L

  * If there is evidence of biliary obstruction by the tumor, then the total bilirubin must be \< 3 x ULN for age
  * Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U/L
* All patients and/or their parents or legal guardians must sign a written informed consent.
* All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Exclusion Criteria:

* Patients who have received prior chemotherapy and/or radiation therapy for cancer prior to enrollment. Surgical resection alone of previous cancer(s) is permitted.
* Patients who have received chemotherapy or radiation for non-malignant conditions (e.g., autoimmune diseases) are eligible. Patients must discontinue chemotherapy for non-malignant conditions prior to starting protocol therapy.
* Vincristine is sensitive substrate of the CYP450 3A4 isozyme. Patients must not have received drugs that are moderate to strong CYP3A4 inhibitors and inducers within 7 days prior to study enrollment.
* Patients unable to undergo radiation therapy, if necessary, as specified in the protocol.
* Evidence of uncontrolled infection.
* Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential.
* Lactating females who plan to breastfeed their infants.
* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation.

Updated 2026-05-05 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.