Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Liquid Biopsy MRD

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Patients aged between 18 and 80
* Patients suspected for high-risk GIST by preoperative imaging examinations or diagnosed with high-risk GIST by pathological biopsy, who have not received preoperative neoadjuvant treatment
* Patients must have not received any treatment including radiotherapy, chemotherapy or surgery
* The function of other organs including liver and kidneys is good enough so that the patients could tolerate targeted therapy and surgery
* Postoperative pathology conformed the diagnosis of high-risk GIST
* Patients and their families could understand the protocol of this study and voluntarily agree to participate in. Signed informed consents are required

Exclusion Criteria:

* Previous medical history of malignant tumors or synchronous other malignancies
* Emergent surgery because of bowel obstruction, perforation or bleeding
* Pregnant or lactant women
* Medical history of severe mental illness
* Patients with contraindication for targeted therapy and surgery
* Non-R0 resection
* Postoperative pathology conformed the diagnosis of non-high-risk GIST
* Patients with distant metastasis
* Other situations in which researchers consider that the patient is unsuitable for this study