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Recruiting nowPhase 3Ages 18 Years and up

Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

Sponsor: NRG Oncology · NCT05646316 on ClinicalTrials.gov ↗

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Conditions studied

Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

What it tests

  • Biospecimen Collectionprocedure
  • Diagnostic Imaging Testingprocedure
  • Excisional Biopsyprocedure
  • Indocyanine Green Solutiondrug
  • Minimally Invasive Surgeryprocedure
  • Pelvic Lymphadenectomyprocedure
  • Questionnaire Administrationother
  • Sentinel Lymph Node Mappingprocedure

Where it's running55 sites

  • George Washington University Medical Center

    Washington D.C., District of Columbia 20037

    Suspended

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida 33146

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Abdulrahman Sinno(principal investigator)

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida 33442

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Abdulrahman Sinno(principal investigator)

  • UM Sylvester Comprehensive Cancer Center at Doral

    Doral, Florida 33166

    Recruiting now

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida 33136

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Abdulrahman Sinno(principal investigator)

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida 33176

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Abdulrahman Sinno(principal investigator)

  • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

    North Miami, Florida 33181

    Recruiting now

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida 33324

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Abdulrahman Sinno(principal investigator)

  • Augusta University Medical Center

    Augusta, Georgia 30912

    Recruiting now

  • Northwestern University

    Chicago, Illinois 60611

    Recruiting now

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois 60555

    Recruiting now

  • IU Health North Hospital

    Carmel, Indiana 46032

    Recruiting now

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana 46202

    Recruiting now

  • West Jefferson Medical Center

    Marrero, Louisiana 70072

    Recruiting now

  • East Jefferson General Hospital

    Metairie, Louisiana 70006

    Recruiting now

  • LSU Healthcare Network / Metairie Multi-Specialty Clinic

    Metairie, Louisiana 70006

    Recruiting now

  • Louisiana State University Health Science Center

    New Orleans, Louisiana 70112

    Recruiting now

  • University Medical Center New Orleans

    New Orleans, Louisiana 70112

    Recruiting now

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland 21201

    Recruiting now
    • Site Public Contact(contact)800-888-8823
    • Gautam G. Rao(principal investigator)

  • UM Upper Chesapeake Medical Center

    Bel Air, Maryland 21014

    Recruiting now
    • Site Public Contact(contact)443-643-3010
    • Gautam G. Rao(principal investigator)

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan 48201

    Recruiting now

  • Weisberg Cancer Treatment Center

    Farmington Hills, Michigan 48334

    Recruiting now

  • McLaren Cancer Institute-Flint

    Flint, Michigan 48532

    Recruiting now

  • Fairview Southdale Hospital

    Edina, Minnesota 55435

    Recruiting now

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota 55369

    Recruiting now

  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota 55109

    Recruiting now

  • Fairview Northland Medical Center

    Princeton, Minnesota 55371

    Recruiting now

  • Regions Hospital

    Saint Paul, Minnesota 55101

    Recruiting now

  • Fairview Lakes Medical Center

    Wyoming, Minnesota 55092

    Recruiting now

  • Mercy Hospital Springfield

    Springfield, Missouri 65804

    Recruiting now
    • Site Public Contact(contact)417-269-4520
    • Jay W. Carlson(principal investigator)

  • Saint Vincent Healthcare

    Billings, Montana 59101

    Active, not recruiting

  • Saint Vincent Frontier Cancer Center

    Billings, Montana 59102

    Active, not recruiting

  • Intermountain Health West End Clinic

    Billings, Montana 59106

    Active, not recruiting

  • Saint James Community Hospital and Cancer Treatment Center

    Butte, Montana 59701

    Active, not recruiting

  • Fred and Pamela Buffett Cancer Center - Kearney

    Kearney, Nebraska 68845

    Recruiting now

  • Nebraska Medicine-Village Pointe

    Omaha, Nebraska 68118

    Recruiting now
    • Site Public Contact(contact)402-559-5600
    • Kerry J. Rodabaugh(principal investigator)

  • Alegent Health Bergan Mercy Medical Center

    Omaha, Nebraska 68124

    Active, not recruiting

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198

    Recruiting now

  • Women's Cancer Center of Nevada

    Las Vegas, Nevada 89106

    Recruiting now
    • Site Public Contact(contact)702-851-4672
    • Nicola M. Spirtos(principal investigator)

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104

    Recruiting now

  • Bryn Mawr Hospital

    Bryn Mawr, Pennsylvania 19010

    Suspended

  • Paoli Memorial Hospital

    Paoli, Pennsylvania 19301

    Suspended

  • Lankenau Medical Center

    Wynnewood, Pennsylvania 19096

    Suspended

  • Women and Infants Hospital

    Providence, Rhode Island 02905

    Recruiting now
    • Site Public Contact(contact)401-274-1122
    • Matthew T. Oliver(principal investigator)

  • Parkland Memorial Hospital

    Dallas, Texas 75235

    Recruiting now

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas 75390

    Recruiting now

  • UT Southwestern/Simmons Cancer Center-Fort Worth

    Fort Worth, Texas 76104

    Recruiting now

  • Houston Methodist Hospital

    Houston, Texas 77030

    Active, not recruiting

  • Memorial Hermann Texas Medical Center

    Houston, Texas 77030

    Recruiting now
    • Site Public Contact(contact)713-792-3245
    • Joseph A. Lucci(principal investigator)

  • Methodist Willowbrook Hospital

    Houston, Texas 77070

    Active, not recruiting

  • Houston Methodist West Hospital

    Houston, Texas 77094

    Active, not recruiting

  • UT Southwestern Clinical Center at Richardson/Plano

    Richardson, Texas 75080

    Recruiting now

  • Houston Methodist Sugar Land Hospital

    Sugar Land, Texas 77479

    Active, not recruiting

  • Houston Methodist The Woodlands Hospital

    The Woodlands, Texas 77385

    Active, not recruiting

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908

    Recruiting now
See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Histologically proven diagnosis of endometrial cancer based on endometrial sampling with a plan to undergo laparoscopic or robotic hysterectomy and lymphatic assessment as part of primary management. Biopsy must be performed within 90 days prior to registration
* Clinical stage I endometrial cancer based on the following diagnostic workup:

  * History/physical examination within 30 days prior to registration is reassuring for the absence of metastatic disease
* Age \>= 18 years
* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1 or 2
* Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
* The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information
* Patients must speak English, Spanish, or Korean

Exclusion Criteria:

* Patients whom the surgeon believes is not a candidate for pelvic lymphadenectomy due to medical comorbidities or other technical challenges (i.e. morbid obesity or prior surgery)
* History of chemotherapy or immunotherapy for the treatment of endometrial cancer. Progestin-containing therapies such as megestrol, medroxyprogesterone, or levonorgestrel-containing intrauterine device (IUD) are acceptable
* History of radiation to the pelvis, groin or lower extremities, or surgery to the pelvic lymph nodes or inguinal lymph nodes
* Patients who are going to undergo another elective surgery during the same operative event as their hysterectomy (i.e., sacrocolpopexy, cholecystectomy)
* Patients with severe, active co-morbidity defined as follows:

  * History of patient or provider identified lower extremity lymphedema
  * History of patient or provider identified chronic lower extremity swelling
  * History of lower extremity or pelvic deep venous thromboembolism within 90 days of registration
  * History of lower extremity cellulitis within 90 days of registration

Updated 2026-03-27 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.