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Recruiting nowPhase 2/3Up to 40 Years

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

Sponsor: National Cancer Institute (NCI) · NCT05691478 on ClinicalTrials.gov ↗

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Conditions studied

High Grade OsteosarcomaLocalized OsteosarcomaMetastatic OsteosarcomaSecondary Osteosarcoma

What it tests

  • Bone Scanprocedure
  • Cabozantinib S-malatedrug
  • Cisplatindrug
  • Computed Tomographyprocedure
  • Doxorubicin Hydrochloridedrug
  • Magnetic Resonance Imagingprocedure
  • Methotrexatedrug
  • Surgical Procedureprocedure
  • X-Ray Imagingprocedure

Where it's running198 sites

  • Children's Hospital of Alabama

    Birmingham, Alabama 35233

    Recruiting now

  • Banner Children's at Desert

    Mesa, Arizona 85202

    Recruiting now
    • Site Public Contact(contact)480-412-3100
    • Joseph C. Torkildson(principal investigator)

  • Phoenix Childrens Hospital

    Phoenix, Arizona 85016

    Recruiting now
    • Site Public Contact(contact)602-546-0920
    • Alok K. Kothari(principal investigator)

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona 85054

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Wendy Allen-Rhoades(principal investigator)

  • Banner University Medical Center - Tucson

    Tucson, Arizona 85719

    Recruiting now

  • Arkansas Children's Hospital

    Little Rock, Arkansas 72202-3591

    Recruiting now
    • Site Public Contact(contact)501-364-7373
    • Michael W. Bishop(principal investigator)

  • Kaiser Permanente Downey Medical Center

    Downey, California 90242

    Recruiting now
    • Site Public Contact(contact)626-564-3455
    • Robert M. Cooper(principal investigator)

  • City of Hope Comprehensive Cancer Center

    Duarte, California 91010

    Recruiting now

  • Loma Linda University Medical Center

    Loma Linda, California 92354

    Recruiting now
    • Site Public Contact(contact)909-558-4050
    • Albert Kheradpour(principal investigator)

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California 90806

    Recruiting now
    • Site Public Contact(contact)562-933-5600
    • Jacqueline N. Casillas(principal investigator)

  • Children's Hospital Los Angeles

    Los Angeles, California 90027

    Recruiting now
    • Site Public Contact(contact)323-361-4110
    • Fariba Navid(principal investigator)

  • Cedars-Sinai Medical Center

    Los Angeles, California 90048

    Recruiting now

  • Mattel Children's Hospital UCLA

    Los Angeles, California 90095

    Recruiting now
    • Site Public Contact(contact)310-825-6708
    • Satiro N. De Oliveira(principal investigator)

  • Valley Children's Hospital

    Madera, California 93636

    Recruiting now

  • UCSF Benioff Children's Hospital Oakland

    Oakland, California 94609

    Recruiting now

  • Kaiser Permanente-Oakland

    Oakland, California 94611

    Recruiting now

  • Children's Hospital of Orange County

    Orange, California 92868

    Recruiting now

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California 94304

    Recruiting now

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California 95817

    Recruiting now
    • Site Public Contact(contact)916-734-3089
    • Marcio H. Malogolowkin(principal investigator)

  • Rady Children's Hospital - San Diego

    San Diego, California 92123

    Recruiting now
    • Site Public Contact(contact)858-966-5934
    • William D. Roberts(principal investigator)

  • UCSF Medical Center-Mission Bay

    San Francisco, California 94158

    Recruiting now

  • Children's Hospital Colorado

    Aurora, Colorado 80045

    Recruiting now

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado 80218

    Recruiting now

  • Connecticut Children's Medical Center

    Hartford, Connecticut 06106

    Recruiting now
    • Site Public Contact(contact)860-545-9981
    • Michael S. Isakoff(principal investigator)

  • Yale University

    New Haven, Connecticut 06520

    Recruiting now

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware 19803

    Recruiting now

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia 20007

    Recruiting now
    • Site Public Contact(contact)202-444-2223
    • Caileigh Pudela(principal investigator)

  • Children's National Medical Center

    Washington D.C., District of Columbia 20010

    Recruiting now

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida 33908

    Recruiting now

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida 32610

    Recruiting now

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida 33021

    Recruiting now

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida 32207

    Recruiting now

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida 33136

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Aditi Dhir(principal investigator)

  • Nicklaus Children's Hospital

    Miami, Florida 33155

    Recruiting now
    • Site Public Contact(contact)888-624-2778
    • Maggie E. Fader(principal investigator)

  • Miami Cancer Institute

    Miami, Florida 33176

    Recruiting now
    • Site Public Contact(contact)786-596-2000
    • Doured Daghistani(principal investigator)

  • AdventHealth Orlando

    Orlando, Florida 32803

    Recruiting now

  • Arnold Palmer Hospital for Children

    Orlando, Florida 32806

    Recruiting now

  • Nemours Children's Hospital

    Orlando, Florida 32827

    Recruiting now

  • Nemours Children's Clinic - Pensacola

    Pensacola, Florida 32504

    Recruiting now

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida 33701

    Recruiting now

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida 33607

    Recruiting now

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia 30329

    Recruiting now

  • Augusta University Medical Center

    Augusta, Georgia 30912

    Recruiting now

  • Memorial Health University Medical Center

    Savannah, Georgia 31404

    Recruiting now

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826

    Recruiting now
    • Site Public Contact(contact)808-983-6090
    • Wade T. Kyono(principal investigator)

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho 83712

    Recruiting now

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois 60611

    Recruiting now
    • Site Public Contact(contact)773-880-4562
    • Jennifer L. Reichek(principal investigator)

  • Northwestern University

    Chicago, Illinois 60611

    Recruiting now

  • University of Illinois

    Chicago, Illinois 60612

    Recruiting now
    • Site Public Contact(contact)312-355-3046
    • Dipti S. Dighe(principal investigator)

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois 60637

    Recruiting now

  • OSF Children's Hospital of Illinois

    Peoria, Illinois 61637

    Recruiting now

  • Riley Hospital for Children

    Indianapolis, Indiana 46202

    Recruiting now
    • Site Public Contact(contact)800-248-1199
    • Sandeep Batra(principal investigator)

  • Blank Children's Hospital

    Des Moines, Iowa 50309

    Recruiting now

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa 52242

    Recruiting now
    • Site Public Contact(contact)800-237-1225
    • Andrew P. Groves(principal investigator)

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky 40536

    Recruiting now
    • Site Public Contact(contact)859-257-3379
    • James T. Badgett(principal investigator)

  • Norton Children's Hospital

    Louisville, Kentucky 40202

    Recruiting now

  • Children's Hospital New Orleans

    New Orleans, Louisiana 70118

    Recruiting now
    • Site Public Contact(contact)504-894-5377
    • Maria C. Velez-Yanguas(principal investigator)

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana 70121

    Recruiting now

  • Eastern Maine Medical Center

    Bangor, Maine 04401

    Recruiting now
    • Site Public Contact(contact)207-973-4274
    • Daniel L. Callaway(principal investigator)

  • Maine Children's Cancer Program

    Scarborough, Maine 04074

    Recruiting now

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland 21201

    Recruiting now
    • Site Public Contact(contact)800-888-8823
    • Teresa A. York(principal investigator)

  • Sinai Hospital of Baltimore

    Baltimore, Maryland 21215

    Recruiting now
    • Site Public Contact(contact)410-601-9083
    • Jason M. Fixler(principal investigator)

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland 21287

    Recruiting now

  • Walter Reed National Military Medical Center

    Bethesda, Maryland 20889-5600

    Recruiting now
    • Site Public Contact(contact)301-319-2100
    • Kip R. Hartman(principal investigator)

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts 02114

    Recruiting now
    • Site Public Contact(contact)877-726-5130
    • Alison M. Friedmann(principal investigator)

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215

    Recruiting now
    • Site Public Contact(contact)877-442-3324
    • Katherine A. Janeway(principal investigator)

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts 01655

    Recruiting now

  • C S Mott Children's Hospital

    Ann Arbor, Michigan 48109

    Recruiting now
    • Site Public Contact(contact)800-865-1125
    • Rama Jasty(principal investigator)

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan 48109

    Recruiting now

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan 48183

    Recruiting now

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan 48038

    Recruiting now

  • Henry Ford Medical Center-Fairlane

    Dearborn, Michigan 48126

    Recruiting now

  • Children's Hospital of Michigan

    Detroit, Michigan 48201

    Recruiting now

  • Henry Ford Hospital

    Detroit, Michigan 48202

    Recruiting now

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan 49503

    Recruiting now

  • Allegiance Health

    Jackson, Michigan 49201

    Recruiting now

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007

    Recruiting now

  • Henry Ford Medical Center-Columbus

    Novi, Michigan 48377

    Recruiting now

  • Corewell Health Children's

    Royal Oak, Michigan 48073

    Recruiting now
    • Site Public Contact(contact)248-551-7695
    • Marie V. Nelson(principal investigator)

  • Henry Ford West Bloomfield Hospital

    West Bloomfield, Michigan 48322

    Recruiting now

  • Henry Ford Wyandotte Hospital

    Wyandotte, Michigan 48192

    Recruiting now

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota 55404

    Recruiting now

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota 55455

    Recruiting now
    • Site Public Contact(contact)612-624-2620
    • Robin L. Williams(principal investigator)

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Wendy Allen-Rhoades(principal investigator)

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216

    Recruiting now
    • Site Public Contact(contact)601-815-6700
    • Amanda Strobel(principal investigator)

  • University of Missouri Children's Hospital

    Columbia, Missouri 65212

    Recruiting now

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri 64108

    Recruiting now

  • Cardinal Glennon Children's Medical Center

    St Louis, Missouri 63104

    Recruiting now
    • Site Public Contact(contact)314-268-4000
    • William S. Ferguson(principal investigator)

  • Washington University School of Medicine

    St Louis, Missouri 63110

    Recruiting now

  • Mercy Hospital Saint Louis

    St Louis, Missouri 63141

    Recruiting now
    • Site Public Contact(contact)314-251-7066
    • Robin D. Hanson(principal investigator)

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska 68114

    Recruiting now
    • Site Public Contact(contact)402-955-3949
    • Jill C. Beck(principal investigator)

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198

    Recruiting now

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada 89135

    Recruiting now

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada 89144

    Recruiting now

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire 03756

    Recruiting now

  • Hackensack University Medical Center

    Hackensack, New Jersey 07601

    Recruiting now
    • Site Public Contact(contact)551-996-2897
    • Katharine Offer(principal investigator)

  • Morristown Medical Center

    Morristown, New Jersey 07960

    Recruiting now
    • Site Public Contact(contact)973-971-5900
    • Kathryn L. Laurie(principal investigator)

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey 08903

    Recruiting now
    • Site Public Contact(contact)732-235-8675
    • Scott Moerdler(principal investigator)

  • Newark Beth Israel Medical Center

    Newark, New Jersey 07112

    Recruiting now

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey 07503

    Recruiting now

  • Albany Medical Center

    Albany, New York 12208

    Recruiting now
    • Site Public Contact(contact)518-262-5513
    • Lauren R. Weintraub(principal investigator)

  • Roswell Park Cancer Institute

    Buffalo, New York 14263

    Recruiting now

  • NYU Langone Hospital - Long Island

    Mineola, New York 11501

    Recruiting now

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York 11040

    Recruiting now
    • Site Public Contact(contact)718-470-3460
    • Carolyn F. Levy(principal investigator)

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York 10016

    Recruiting now

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York 10032

    Recruiting now

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Damon R. Reed(principal investigator)

  • NYP/Weill Cornell Medical Center

    New York, New York 10065

    Recruiting now
    • Site Public Contact(contact)212-746-1848
    • Alexander J. Chou(principal investigator)

  • University of Rochester

    Rochester, New York 14642

    Recruiting now
    • Site Public Contact(contact)585-275-5830
    • Rafi R. Kazi(principal investigator)

  • Stony Brook University Medical Center

    Stony Brook, New York 11794

    Recruiting now
    • Site Public Contact(contact)800-862-2215
    • Laura E. Hogan(principal investigator)

  • State University of New York Upstate Medical University

    Syracuse, New York 13210

    Recruiting now
    • Site Public Contact(contact)315-464-5476
    • Melanie A. Comito(principal investigator)

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York 10467

    Recruiting now

  • New York Medical College

    Valhalla, New York 10595

    Recruiting now
    • Site Public Contact(contact)914-594-3794
    • Andrew J. Bellantoni(principal investigator)

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina 27599

    Recruiting now

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina 28203

    Recruiting now
    • Site Public Contact(contact)800-804-9376
    • Joel A. Kaplan(principal investigator)

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina 28204

    Recruiting now

  • Atrium Health Pineville/LCI-Pineville

    Charlotte, North Carolina 28210

    Recruiting now
    • Site Public Contact(contact)980-442-2000
    • Joel A. Kaplan(principal investigator)

  • Duke University Medical Center

    Durham, North Carolina 27710

    Recruiting now
    • Site Public Contact(contact)888-275-3853
    • Jessica M. Sun(principal investigator)

  • East Carolina University

    Greenville, North Carolina 27834

    Recruiting now

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina 27157

    Recruiting now
    • Site Public Contact(contact)336-713-6771
    • Sarah Supples(principal investigator)

  • Sanford Broadway Medical Center

    Fargo, North Dakota 58122

    Recruiting now

  • Children's Hospital Medical Center of Akron

    Akron, Ohio 44308

    Recruiting now
    • Site Public Contact(contact)330-543-3193
    • Erin Wright(principal investigator)

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio 45229

    Recruiting now

  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio 44106

    Recruiting now
    • Site Public Contact(contact)216-844-5437
    • Duncan S. Stearns(principal investigator)

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195

    Recruiting now

  • Nationwide Children's Hospital

    Columbus, Ohio 43205

    Recruiting now

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210

    Recruiting now

  • Dayton Children's Hospital

    Dayton, Ohio 45404

    Recruiting now
    • Site Public Contact(contact)800-228-4055
    • Jordan M. Wright(principal investigator)

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    Toledo, Ohio 43606

    Recruiting now

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104

    Recruiting now

  • Legacy Emanuel Children's Hospital

    Portland, Oregon 97227

    Recruiting now
    • Site Public Contact(contact)503-413-2560
    • Jason M. Glover(principal investigator)

  • Oregon Health and Science University

    Portland, Oregon 97239

    Recruiting now

  • Geisinger Medical Center

    Danville, Pennsylvania 17822

    Recruiting now

  • Penn State Children's Hospital

    Hershey, Pennsylvania 17033

    Recruiting now
    • Site Public Contact(contact)717-531-6012
    • Lisa M. McGregor(principal investigator)

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania 19104

    Recruiting now

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania 19107

    Recruiting now

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania 19134

    Recruiting now
    • Site Public Contact(contact)215-427-8991
    • Gregory E. Halligan(principal investigator)

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania 15224

    Recruiting now

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania 15232

    Recruiting now
    • Site Public Contact(contact)412-647-8073
    • Melissa A. Burgess(principal investigator)

  • Medical University of South Carolina

    Charleston, South Carolina 29425

    Recruiting now

  • Prisma Health Richland Hospital

    Columbia, South Carolina 29203

    Recruiting now

  • Saint Francis Hospital

    Greenville, South Carolina 29601

    Recruiting now

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina 29605

    Recruiting now

  • Saint Francis Cancer Center

    Greenville, South Carolina 29607

    Recruiting now

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota 57117-5134

    Recruiting now

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee 37916

    Recruiting now
    • Site Public Contact(contact)865-541-8266
    • Susan E. Spiller(principal investigator)

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee 38105

    Recruiting now

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee 37203

    Recruiting now
    • Site Public Contact(contact)615-342-1919
    • Clinton M. Carroll(principal investigator)

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee 37232

    Recruiting now
    • Site Public Contact(contact)800-811-8480
    • Scott C. Borinstein(principal investigator)

  • Dell Children's Medical Center of Central Texas

    Austin, Texas 78723

    Recruiting now

  • Driscoll Children's Hospital

    Corpus Christi, Texas 78411

    Recruiting now

  • Medical City Dallas Hospital

    Dallas, Texas 75230

    Recruiting now
    • Site Public Contact(contact)972-566-5588
    • Maurizio L. Ghisoli(principal investigator)

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas 75390

    Recruiting now

  • El Paso Children's Hospital

    El Paso, Texas 79905

    Recruiting now

  • Cook Children's Medical Center

    Fort Worth, Texas 76104

    Recruiting now

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas 77030

    Recruiting now

  • UT MD Anderson Cancer Center

    Houston, Texas 77030

    Recruiting now

  • Covenant Children's Hospital

    Lubbock, Texas 79410

    Recruiting now

  • UMC Cancer Center / UMC Health System

    Lubbock, Texas 79415

    Recruiting now
    • Site Public Contact(contact)806-775-8590
    • Erin K. Barr(principal investigator)

  • Children's Hospital of San Antonio

    San Antonio, Texas 78207

    Recruiting now

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas 78229

    Recruiting now

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas 78229

    Recruiting now

  • Scott and White Memorial Hospital

    Temple, Texas 76508

    Recruiting now
    • Site Public Contact(contact)254-724-5407
    • Nicholas W. McGregor(principal investigator)

  • Primary Children's Hospital

    Salt Lake City, Utah 84113

    Recruiting now
    • Site Public Contact(contact)801-585-5270
    • Matthew Dietz(principal investigator)

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908

    Recruiting now

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia 23507

    Recruiting now

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia 23235

    Suspended

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia 23298

    Recruiting now

  • Seattle Children's Hospital

    Seattle, Washington 98105

    Recruiting now
    • Site Public Contact(contact)866-987-2000
    • Sarah E. Leary(principal investigator)

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington 99204

    Recruiting now

  • Mary Bridge Children's Hospital and Health Center

    Tacoma, Washington 98405

    Recruiting now

  • Madigan Army Medical Center

    Tacoma, Washington 98431

    Recruiting now

  • West Virginia University Charleston Division

    Charleston, West Virginia 25304

    Recruiting now
    • Site Public Contact(contact)304-388-9944
    • Mohamad H. Badawi(principal investigator)

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin 54301

    Recruiting now

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin 53792

    Recruiting now

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin 54449

    Recruiting now

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin 53226

    Recruiting now
21 international sites

  • Sydney Children's Hospital

    Randwick, New South Wales, Australia 2031

    Recruiting now
    • Site Public Contact(contact)(02) 9382-1721
    • Draga Barbaric(principal investigator)

  • The Children's Hospital at Westmead

    Westmead, New South Wales, Australia 2145

    Recruiting now
    • Site Public Contact(contact)61-2-9845 1400
    • Bhavna Padhye(principal investigator)

  • Queensland Children's Hospital

    South Brisbane, Queensland, Australia 4101

    Recruiting now
    • Site Public Contact(contact)61 7 3068 1111
    • Steven A. Foresto(principal investigator)

  • Women's and Children's Hospital-Adelaide

    North Adelaide, South Australia, Australia 5006

    Recruiting now

  • Monash Medical Center-Clayton Campus

    Clayton, Victoria, Australia 3168

    Recruiting now
    • Site Public Contact(contact)(03) 9928 8111
    • Michelle Martin(principal investigator)

  • Royal Children's Hospital

    Parkville, Victoria, Australia 3052

    Recruiting now

  • Perth Children's Hospital

    Perth, Western Australia, Australia 6009

    Recruiting now

  • Alberta Children's Hospital

    Calgary, Alberta, Canada T3B 6A8

    Recruiting now

  • University of Alberta Hospital

    Edmonton, Alberta, Canada T6G 2B7

    Recruiting now

  • CancerCare Manitoba

    Winnipeg, Manitoba, Canada R3E 0V9

    Recruiting now

  • IWK Health Centre

    Halifax, Nova Scotia, Canada B3K 6R8

    Recruiting now

  • Children's Hospital

    London, Ontario, Canada N6A 5W9

    Recruiting now
    • Site Public Contact(contact)519-685-8306
    • Shayna M. Zelcer(principal investigator)

  • Children's Hospital of Eastern Ontario

    Ottawa, Ontario, Canada K1H 8L1

    Recruiting now
    • Site Public Contact(contact)613-737-7600
    • Donna L. Johnston(principal investigator)

  • Hospital for Sick Children

    Toronto, Ontario, Canada M5G 1X8

    Recruiting now

  • The Montreal Children's Hospital of the MUHC

    Montreal, Quebec, Canada H3H 1P3

    Recruiting now

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, Canada H3T 1C5

    Recruiting now

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, Canada J1H 5N4

    Recruiting now

  • Jim Pattison Children's Hospital

    Saskatoon, Saskatchewan, Canada S7N 0W8

    Recruiting now

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    Québec, Canada G1V 4G2

    Recruiting now

  • Starship Children's Hospital

    Grafton, Auckland, New Zealand 1145

    Recruiting now
    • Site Public Contact(contact)0800 728 436
    • Mandy PohLui de Silva(principal investigator)

  • Christchurch Hospital

    Christchurch, New Zealand 8011

    Recruiting now
    • Site Public Contact(contact)03 364 0640
    • Tristan Pettit(principal investigator)
See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Patients must be \< 40 years of age at the time of enrollment.
* Patients must have a body surface area of \>= 0.8 m\^2 at the time of enrollment.
* Patients must have histologic diagnosis (by institutional pathologist) of newly diagnosed high grade osteosarcoma. Primary tumors of all extremity and axial sites are eligible as long as diagnosis of high-grade osteosarcoma is established. Osteosarcoma as a second malignancy is eligible if no prior exposure to systemic chemotherapies.
* Feasibility Phase (NOTE: as of Amendment #2B, the feasibility phase has been completed) Patients must have metastatic disease and a resectable primary tumor. Designation of a primary tumor as resectable will be determined at the time of diagnosis by the institutional multidisciplinary team.

For this study, metastatic disease is defined as one or more of the following:

* Lesions which are discontinuous from the primary tumor, are not regional lymph nodes, and do not share a bone or body cavity with the primary tumor. Skip lesions in the same bone as the primary tumor do not constitute metastatic disease. Skip lesions in an adjacent bone are considered bone metastases.
* Lung metastases: defined as biopsy-proven metastasis or the presence of one or more pulmonary lesions \>= 5 mm, OR multiple pulmonary lesions \>= 3 mm or greater in size.
* Bone metastases: Areas suspicious for bone metastasis based on fludeoxyglucose F-18 (18F-FDG)-positron emission tomography (PET) scan (or whole body technetium-99 bone scan if 18F-FDG-PET is unavailable at the treating institution) require confirmatory biopsy or supportive anatomic imaging of at least one suspicious site with either magnetic resonance imaging (MRI) or computed tomography (CT) (whole body 18F-FDG-PET/CT or 18F-FDG-PET/MR scans are acceptable).

  * Efficacy Phases (Phase 2/3) NOTE: as of Amendment #2B, the efficacy phase is open for enrollment.

Patients with both localized and metastatic disease are eligible for the efficacy phase, regardless of resectability. Patients will be enrolled to two separate cohorts:

* Cohort 1 (Standard Risk): Patients with non-pelvic primary osteosarcoma deemed to be resectable at the time of diagnosis by the institutional multidisciplinary team, without evidence of metastatic lesions.
* Cohort 2 (High-Risk): Patients with a primary pelvic tumor, a primary tumor designated as unresectable by the institutional multidisciplinary team, AND/OR radiographic evidence of metastatic lesions.

  * A serum creatinine based on age/sex as follows (within 7 days prior to enrollment unless otherwise indicated):
* (Age: Maximum Serum Creatinine \[mg/dL\]; Sex)

  * 1 month to \< 6 months: 0.4 (male); 0.4 (female)
  * 6 months to \< 1 year: 0.5 (male); 0.5 (female)
  * 1 to \< 2 years: 0.6 (male); 0.6 (female)
  * 2 to \< 6 years: 0.8 (male); 0.8 (female)
  * 6 to \< 10 years: 1 (male); 1 (female)
  * 10 to \< 13 years: 1.2 (male); 1.2 (female)
  * 13 to \< 16 years: 1.5 (male); 1.4 (female)
  * \>= 16 years: 1.7 (male); 1.4 (female)
* OR - a 24 hour urine creatinine clearance \>= 70 mL/min/1.73 m\^2
* OR - a glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2. GFR must be performed using direct measurement with a nuclear blood sampling method OR direct small molecule clearance method (iothalamate or other molecule per institutional standard).

  * Note: Estimated GFR (eGFR) from serum creatinine, cystatin C or other estimates are not acceptable for determining eligibility.

    * Total bilirubin =\< 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment unless otherwise indicated)
    * Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) =\< 135 U/L (within 7 days prior to enrollment unless otherwise indicated)
* Note: For the purpose of this study, the ULN for SGPT (ALT) has been set to the value of 45 U/L

  * No history of congenital prolonged corrected QT (QTc) syndrome, New York Heart Association (NYHA) Class III or IV congestive heart failure, unstable angina pectoris, serious cardiac arrhythmias
* Shortening fraction of \>= 27%, or
* Ejection fraction of \>= 50%
* Corrected QT interval by Fridericia (QTcF) \< 480 msec on electrocardiogram. Patients with Grade 1 prolonged QTc (450-480 msec) at time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e., electrolytes, medications).

  * Peripheral absolute neutrophil count (ANC) \>= 1000/uL (within 7 days prior to enrollment unless otherwise indicated)
  * Platelet count \>= 100,000/uL (transfusion independent, defined as not receiving platelet transfusions within a 7-day period prior to enrollment) (within 7 days prior to enrollment unless otherwise indicated)
  * Hemoglobin \>= 8.0 g/dL (within 7 days prior to enrollment unless otherwise indicated)
  * International normalized ratio (INR) =\< 1.5 (within 7 days prior to enrollment unless otherwise indicated)
  * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible as long as they are NOT receiving anti-retroviral agents that are strong inhibitors or inducers of CYP3A4, CYP2D6, and/or MRP2 transporter protein.
  * All patients and/or their parents or legal guardians must sign a written informed consent.
  * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.

Exclusion Criteria:

* Patients who have received previous systemic therapy for osteosarcoma or a prior oncologic diagnosis.
* Patients who have central nervous system metastases.
* Patients with central cavitating pulmonary lesions invading or encasing any major blood vessels in the lung.
* Patients who are unable to swallow tablets. Tablets cannot be crushed or chewed.
* Patients with gastrointestinal disorders including active disorders associated with a high risk of perforation or fistula formation. Specifically, no clinically significant gastrointestinal (GI) bleeding, GI perforation, bowel obstruction, intra-abdominal abscess or fistula for 6 months prior to enrollment, no hemoptysis or other signs of pulmonary hemorrhage for 3 months prior to enrollment.
* Patients with active bleeding or bleeding diathesis. No clinically significant hematuria, hematemesis, or hemoptysis or other history of significant bleeding within 3 months prior to enrollment.
* Patients with uncompensated or symptomatic hypothyroidism. Patients who have hypothyroidism controlled with thyroid replacement hormone are eligible.
* Patients with moderate to severe hepatic impairment (Child-Pugh B or C).
* Patients who have had primary tumor resection or attempted curative resection of metastases prior to enrollment.
* Patients who have undergone other major surgical procedure (eg, laparotomy) within 14 days prior to enrollment. Thoracoscopic procedures for diagnostic purposes (biopsy of lung nodule) and central access such as port-a-cath placement are allowed.
* Patients with a history of serious or non-healing wound or bone fracture (pathologic fracture of primary tumor is not considered exclusion).
* Patients with any medical or surgical conditions that would interfere with gastrointestinal absorption of cabozantinib.
* Patients with previously identify allergy or hypersensitivity to components of the study treatment formulations.
* Patients who are receiving any other investigational agent not defined within this protocol are not eligible.
* Patients who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study are not eligible.
* Patients who received enzyme-inducing anticonvulsants within 14 days prior to enrollment.
* Patients with a prior history of hypertension (\> 95th percentile for age, height, and sex for patients \< 18 years and \> 140/90 mmHg for patients \>= 18 years requiring medication for blood pressure control.
* Patients who are receiving drugs that prolong QTc.
* Patients receiving anticoagulation with oral coumarin agents (eg warfarin), direct thrombin inhibitors (eg dabigatran), direct factor Xa inhibitor betrixaban, or platelet inhibitors (eg, clopidogrel). Low dose aspirin for cardioprotection (per local applicable guidelines) and low dose, low molecular weight heparins (LMWH) are permitted. Anticoagulation with therapeutic doses of LMWH and direct factor Xa inhibitors rivaroxaban or apixaban are allowed in subjects who are on a stable dose for at least 6 weeks before the first dose of study treatment, and who have had no complications from a thromboembolic event or the anticoagulation regimen.
* Patients receiving strong CYP3A4 inducers or strong CYP3A4 inhibitors.
* Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential.
* Lactating females who plan to breastfeed their infants.
* Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of protocol therapy.

Updated 2026-06-18 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.