Multi-parametric Imaging in Personalized Radiotherapy

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Patients with histologically confirmed diagnosis of chordoma of the skull base
* Particle therapy with curative intent
* Karnofsky Performance status greater than or equal to 60
* Patients with macroscopic disease detectable at pre-radiotherapy imaging
* Patients undergoing PT with standardized treatment procedures
* Patients who have signed the written informed consent for research

Exclusion Criteria:

* Metastatic disease
* Palliative treatment
* Other malignancies with disease-free interval \< 5 years (excepting pre- cancerous lesions)
* Pregnancy
* Simultaneous CHT or Immunotherapy
* Extensive metal instrumentation/implants
* Patients with autoimmune diseases (ADs) -including collagen-vascular (CVD) and inflammatory bowel (IBD)