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Recruiting nowPhase 3Ages 18 Years and up

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Sponsor: Merck Sharp & Dohme LLC · NCT06345729 on ClinicalTrials.gov ↗

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Conditions studied

Non-small Cell Lung Cancer

What it tests

  • Calderasibdrug
  • Placeboother
  • Pembrolizumabbiological

Where it's running225 sites

  • CBCC Global Research, Inc. ( Site 0123)

    Bakersfield, California 93309

    Recruiting now

  • Beverly Hills Cancer Center ( Site 0116)

    Beverly Hills, California 90211

    Recruiting now

  • Stamford Hospital ( Site 0136)

    Stamford, Connecticut 06902

    Recruiting now

  • Mount Sinai Cancer Center ( Site 0137)

    Miami Beach, Florida 33140

    Completed

  • Orchard Healthcare Research Inc. ( Site 0115)

    Skokie, Illinois 60077

    Recruiting now

  • Truman Medical Center ( Site 0126)

    Kansas City, Missouri 64108

    Recruiting now

  • Cox Medical Center North ( Site 0133)

    Springfield, Missouri 65807

    Recruiting now

  • St. Vincent Frontier Cancer Center-Research ( Site 0105)

    Billings, Montana 59102

    Recruiting now

  • Atlantic Health System Morristown Medical Center ( Site 0121)

    Morristown, New Jersey 07960

    Recruiting now

  • New York Oncology Hematology, P.C. ( Site 0132)

    Albany, New York 12206

    Recruiting now

  • University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0103)

    Cincinnati, Ohio 45219

    Recruiting now

  • Kettering Health Main Campus-Kettering Health Cancer Center ( Site 0106)

    Kettering, Ohio 45429

    Completed

  • Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0134)

    Lancaster, Pennsylvania 17601

    Recruiting now

  • Oncology Consultants P.A. ( Site 0113)

    Houston, Texas 77030

    Recruiting now

  • Circuit Clinical/SSM Health Dean Medical Group ( Site 0129)

    Madison, Wisconsin 53715

    Recruiting now
210 international sites

  • AUSTRAL MEDICAL CENTER ( Site 0302)

    CABA, Buenos Aires, Argentina C1019ABS

    Completed

  • Centro Oncologico Korben ( Site 0304)

    CABA, Buenos Aires, Argentina C1426AGE

    Recruiting now

  • Instituto de Investigaciones Clínicas Mar del Plata ( Site 0300)

    Mar del Plata, Buenos Aires, Argentina B7600FZO

    Recruiting now

  • Fundacion Estudios Clinicos ( Site 0306)

    Rosario, Santa Fe Province, Argentina S2000DEJ

    Recruiting now

  • Sanatorio Parque ( Site 0301)

    Rosario, Santa Fe Province, Argentina S2000DSV

    Recruiting now

  • Chris O'Brien Lifehouse ( Site 3000)

    Camperdown, New South Wales, Australia 2050

    Recruiting now

  • Cancer Care Service Hervey Bay ( Site 3003)

    Urraween, Queensland, Australia 4655

    Recruiting now

  • Frankston Hospital ( Site 3002)

    Frankston, Victoria, Australia 3199

    Recruiting now

  • One Clinical Research ( Site 3001)

    Nedlands, Western Australia, Australia 6009

    Recruiting now

  • Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 2401)

    Graz, Styria, Austria 8036

    Recruiting now

  • Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2400)

    Vienna, Austria 1210

    Recruiting now

  • Hospital Mario Penna ( Site 0436)

    Belo Horizonte, Minas Gerais, Brazil 30380-472

    Recruiting now

  • Hospital de Câncer de Recife ( Site 0447)

    Recife, Pernambuco, Brazil 50040-000

    Recruiting now

  • Oncoclínica Oncologistas Associados ( Site 0441)

    Teresina, Piauí, Brazil 64049-200

    Recruiting now

  • Liga Norte Riograndense Contra o Câncer ( Site 0439)

    Natal, Rio Grande do Norte, Brazil 59062-000

    Recruiting now

  • Hospital de Caridade de Ijuí ( Site 0438)

    Ijuí, Rio Grande do Sul, Brazil 98700 000

    Recruiting now

  • Hospital de Clínicas de Passo Fundo ( Site 0442)

    Passo Fundo, Rio Grande do Sul, Brazil 99010-260

    Recruiting now

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre-Centro Multidisciplinar de Pesquisa Clínica ( Site 0435)

    Porto Alegre, Rio Grande do Sul, Brazil 90050-170

    Recruiting now

  • Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0437)

    Barretos, São Paulo, Brazil 14784-400

    Recruiting now

  • Instituto Nacional de Câncer - INCA ( Site 0446)

    Rio de Janeiro, Brazil 20230-130

    Recruiting now

  • Americas ( Site 0431)

    Rio de Janeiro, Brazil 22775-001

    Recruiting now

  • MBAL Uni Hospital-Department of Medical Oncology ( Site 1000)

    Panagyurishte, Pazardzhik, Bulgaria 4500

    Recruiting now

  • Multiprofile Hospital for Active Treatment SerdikaМЕD EOOD-Second Department of Medical Oncology ( Site 1002)

    Sofia, Sofia (stolitsa), Bulgaria 1632

    Recruiting now

  • MHAT - Heart and Brain ( Site 1006)

    Pleven, Bulgaria 5804

    Recruiting now

  • Medical Center Futuremeds ( Site 1007)

    Plovdiv, Bulgaria 4000

    Recruiting now

  • Complex Oncology Center - Plovdiv EOOD ( Site 1003)

    Plovdiv, Bulgaria 4004

    Recruiting now

  • CancerCare Manitoba ( Site 0210)

    Winnipeg, Manitoba, Canada R3E 0V9

    Recruiting now

  • QEII Health Sciences Centre - Victoria General Site-Dept. of Medical Oncology ( Site 0208)

    Halifax, Nova Scotia, Canada B3H 2Y9

    Recruiting now

  • Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0205)

    Hamilton, Ontario, Canada L8V 5C2

    Recruiting now

  • Sunnybrook Research Institute ( Site 0206)

    Toronto, Ontario, Canada M4N 3M5

    Recruiting now

  • St. Marys Hospital Center ( Site 0204)

    Montreal, Quebec, Canada H3T 1M5

    Recruiting now

  • Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0207)

    Trois-Rivières, Quebec, Canada G8Z 3R9

    Recruiting now

  • Clinica Universidad Catolica del Maule-Oncology ( Site 0500)

    Talca, Maule Region, Chile 3465584

    Recruiting now

  • Orlandi Oncologia-Oncology ( Site 0503)

    Santiago, Region M. de Santiago, Chile 7500713

    Recruiting now

  • FALP-UIDO ( Site 0501)

    Santiago, Region M. de Santiago, Chile 7500921

    Recruiting now

  • Centro de Oncología de Precisión-Oncology ( Site 0502)

    Santiago, Region M. de Santiago, Chile 7560908

    Recruiting now

  • Bradfordhill-Clinical Area ( Site 0504)

    Santiago, Region M. de Santiago, Chile 8420383

    Recruiting now

  • Anhui Provincial Cancer Hospital ( Site 3136)

    Hefei, Anhui, China 230031

    Recruiting now

  • Beijing Cancer hospital ( Site 3133)

    Beijing, Beijing Municipality, China 100142

    Recruiting now

  • Beijing Cancer hospital ( Site 3134)

    Beijing, Beijing Municipality, China 100142

    Recruiting now

  • Beijing Peking Union Medical College Hospital-pneumology department ( Site 3102)

    Beijing, Beijing Municipality, China 100730

    Recruiting now

  • Beijing Chest Hospital,Capital Medical University ( Site 3104)

    Beijing, Beijing Municipality, China 101149

    Recruiting now

  • Chongqing University Cancer Hospital ( Site 3119)

    Chongqing, Chongqing Municipality, China 400030

    Recruiting now

  • Army Medical Center of People's Liberation Army ( Site 3142)

    Chongqing, Chongqing Municipality, China 400042

    Recruiting now

  • Fujian Cancer Hospital ( Site 3127)

    Fuzhou, Fujian, China 350014

    Recruiting now

  • The First Affiliated hospital of Xiamen University ( Site 3148)

    Xiamen, Fujian, China 361003

    Recruiting now

  • The First Affiliated Hospital of Guangzhou Medical University ( Site 3108)

    Guangzhou, Guangdong, China 510160

    Recruiting now

  • Southern Medical University Nanfang Hospital ( Site 3128)

    Guangzhou, Guangdong, China 510515

    Recruiting now

  • Sun Yat-sen University Cancer Center ( Site 3137)

    Guangzhou, Guangdong, China 510555

    Recruiting now

  • Harbin Medical University Cancer Hospital ( Site 3123)

    Harbin, Heilongjiang, China 150081

    Recruiting now

  • JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 3124)

    Jiamusi, Heilongjiang, China 154007

    Recruiting now

  • Henan Cancer Hospital ( Site 3149)

    Zhengzhou, Henan, China 450008

    Recruiting now

  • Tongji Hospital Tongji Medical,Science & Technology ( Site 3113)

    Wuhan, Hubei, China 430000

    Recruiting now

  • Hubei Cancer Hospital ( Site 3126)

    Wuhan, Hubei, China 430079

    Recruiting now

  • The Second Xiangya Hospital of Central South University ( Site 3130)

    Changsha, Hunan, China 410011

    Recruiting now

  • Hunan Cancer Hospital ( Site 3141)

    Changsha, Hunan, China 410013

    Recruiting now

  • Nanjing Gulou Hospital ( Site 3122)

    Nanjing, Jiangsu, China 210008

    Recruiting now

  • Nanjing First Hospital ( Site 3154)

    Nanjing, Jiangsu, China 210012

    Active, not recruiting

  • The First Affiliated Hospital of Soochow University ( Site 3146)

    Suzhou, Jiangsu, China 215006

    Completed

  • Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 3155)

    Wuxi, Jiangsu, China 214122

    Recruiting now

  • The Second Affiliated Hospital of Nanchang University ( Site 3139)

    Nanchang, Jiangxi, China 330000

    Active, not recruiting

  • The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3138)

    Nanchang, Jiangxi, China 330209

    Recruiting now

  • Jilin Province Tumor Hospital ( Site 3107)

    Changchun, Jilin, China 130000

    Recruiting now

  • The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3150)

    Xi'an, Shaanxi, China 710000

    Recruiting now

  • Shandong Cancer Hospital ( Site 3116)

    Jinan, Shandong, China 250117

    Recruiting now

  • LinYi Cancer Hospital ( Site 3111)

    Linyi, Shandong, China 276001

    Recruiting now

  • Shanghai Chest Hospital ( Site 3100)

    Shanghai, Shanghai Municipality, China 200030

    Recruiting now

  • Fudan University Shanghai Cancer Center ( Site 3144)

    Shanghai, Shanghai Municipality, China 200032

    Recruiting now

  • Zhongshan Hospital,Fudan University ( Site 3143)

    Shanghai, Shanghai Municipality, China 200032

    Recruiting now

  • Shanxi Cancer Hospital ( Site 3131)

    Taiyuan, Shanxi, China 030000

    Recruiting now

  • The Second Affiliated Hospital of Air Force Medical University ( Site 3117)

    Xian, Shanxi, China 710038

    Active, not recruiting

  • The Second Affiliated Hospital of Air Force Medical University ( Site 3152)

    Xian, Shanxi, China 710038

    Recruiting now

  • West China Hospital, Sichuan University ( Site 3140)

    Chengdu, Sichuan, China 610000

    Recruiting now

  • The Third People's Hospital of Chengdu (CDTPH) ( Site 3157)

    Chengdu, Sichuan, China 610031

    Recruiting now

  • Sichuan Cancer hospital. ( Site 3109)

    Chengdu, Sichuan, China 610042

    Recruiting now

  • The Second People's Hospital of Neijiang ( Site 3105)

    Neijiang, Sichuan, China 641000

    Recruiting now

  • Xinjiang Medical University Cancer Hospital - Urumqi ( Site 3101)

    Ürümqi, Xinjiang, China 830000

    Completed

  • Yunnan Province Cancer Hospital ( Site 3153)

    Kunming, Yunnan, China 650107

    Recruiting now

  • The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3115)

    Hangzhou, Zhejiang, China 310006

    Recruiting now

  • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 3121)

    Hangzhou, Zhejiang, China 310016

    Recruiting now

  • Taizhou Hospital of Zhejiang Province ( Site 3145)

    Linhai, Zhejiang, China 317000

    Recruiting now

  • The First Affiliated Hospital of Wenzhou Medical University ( Site 3151)

    Wenzhou, Zhejiang, China 325015

    Recruiting now

  • Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1103)

    Dijon, Bourgogne-Franche-Comté, France 21000

    Recruiting now

  • Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 1106)

    Nîmes, Gard, France 30029

    Recruiting now

  • Clinique Teissier Groupe ( Site 1100)

    Valenciennes, Nord, France 59304

    Recruiting now

  • Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1101)

    Clermont-Ferrand, Puy-de-Dome, France 63003

    Recruiting now

  • Centre Hospitalier d'Avignon-Service d'Oncologie médicale et d'hématologie clinique ( Site 1104)

    Avignon, Vaucluse, France 84000

    Recruiting now

  • Hôpital Ambroise Paré-Department of Respiratory Diseases and Thoracic Oncology ( Site 1105)

    Boulogne-Billancourt, Île-de-France Region, France 92100

    Recruiting now

  • High Technology Hospital Medcenter ( Site 1203)

    Batumi, Adjara, Georgia 6000

    Recruiting now

  • Caucasus Medical Centre ( Site 1202)

    Tbilisi, Adjara, Georgia 0186

    Recruiting now

  • American Hospital Network LLC ( Site 1208)

    Tbilisi, Georgia 0102

    Recruiting now

  • Todua Clinic, LLC ( Site 1204)

    Tbilisi, Georgia 0112

    Recruiting now

  • TSMU and Ingorokva High Medical Technology University Clinic LTD ( Site 1201)

    Tbilisi, Georgia 0144

    Completed

  • New Hospitals ( Site 1200)

    Tbilisi, Georgia 0162

    Recruiting now

  • Cancer Research Centre. Mardaleishvili Medical Centre ( Site 1205)

    Tbilisi, Georgia 0177

    Recruiting now

  • Tbilisi Institute of Medicine ( Site 1206)

    Tbilisi, Georgia 1206

    Completed

  • Marienhospital Stuttgart ( Site 1302)

    Stuttgart, Baden-Wurttemberg, Germany 70199

    Recruiting now

  • Evangelisches Krankenhaus Bielefeld - Johannesstift ( Site 1307)

    Bielefeld, North Rhine-Westphalia, Germany 33611

    Recruiting now

  • Krankenhaus Bethanien ( Site 1303)

    Solingen, North Rhine-Westphalia, Germany 42699

    Recruiting now

  • UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1402)

    Pátrai, Achaia, Greece 26504

    Recruiting now

  • Agios Savvas Regional Cancer Hospital-2nd Medical Oncology Department ( Site 1407)

    Athens, Attica, Greece 115 22

    Recruiting now

  • THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1400)

    Athens, Attica, Greece 115 27

    Recruiting now

  • Athens Medical Center ( Site 1406)

    Marousi, Attica, Greece 151 25

    Recruiting now

  • University General Hospital of Larissa-Oncology Clinic ( Site 1403)

    Larissa, Thessaly, Greece 411 10

    Recruiting now

  • Agios Loukas Clinic ( Site 1404)

    Thessaloniki, Greece 552 36

    Recruiting now

  • G. Papanikolaou General Hospital-Pulmonary Clinic of Aristotle University of Thessaloniki ( Site 1405)

    Thessaloniki, Greece 570 10

    Recruiting now

  • Sir H. N. Reliance Foundation Hospital and Research Centre ( Site 3201)

    Mumbai, Maharashtra, India 400004

    Recruiting now

  • Tata Memorial Hospital ( Site 3205)

    Mumbai, Maharashtra, India 400012

    Recruiting now

  • AIIMS New Delhi Dept of Medicine ( Site 3206)

    New Delhi, National Capital Territory of Delhi, India 110029

    Recruiting now

  • Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3203)

    New Delhi, National Capital Territory of Delhi, India 110076

    Recruiting now

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1607)

    Naples, Campania, Italy 80131

    Recruiting now

  • Ospedale Santa Maria delle Croci ( Site 1606)

    Ravenna, Emilia-Romagna, Italy 48121

    Recruiting now

  • CRO-IRCCS-Clinical Oncology ( Site 1605)

    Aviano, Friuli Venezia Giulia, Italy 33081

    Recruiting now

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1601)

    Rome, Lazio, Italy 00168

    Recruiting now

  • Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1600)

    Milan, Lombardy, Italy 20133

    Recruiting now

  • Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1604)

    Milan, Lombardy, Italy 20141

    Recruiting now

  • A.O.R.N. Ospedale dei Colli - Monaldi V.-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 1602)

    Naples, Napoli, Italy 80131

    Recruiting now

  • Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1609)

    Rome, Roma, Italy 00144

    Recruiting now

  • Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno-UOC Oncologia Medica Livorno ( Site 1608)

    Livorno, Tuscany, Italy 57124

    Recruiting now

  • IOV - Istituto Oncologico Veneto IRCCS UOSD - Unità di ricerca clinica ( Site 1603)

    Padova, Italy 35131

    Recruiting now

  • Nagoya University Hospital ( Site 3309)

    Nagoya, Aichi-ken, Japan 466-8560

    Recruiting now

  • Fujita Health University Hospital ( Site 3310)

    Toyoake, Aichi-ken, Japan 470-1192

    Recruiting now

  • National Cancer Center Hospital East ( Site 3303)

    Kashiwa, Chiba, Japan 277-8577

    Recruiting now

  • National Hospital Organization Shikoku Cancer Center ( Site 3315)

    Matsuyam, Ehime, Japan 719-0280

    Recruiting now

  • National Hospital Organization Kyushu Cancer Center ( Site 3316)

    Fukuoka, Fukuoka, Japan 811-1395

    Recruiting now

  • Kurume University Hospital ( Site 3317)

    Kurume, Fukuoka, Japan 830-0011

    Recruiting now

  • Gunma Prefectural Cancer Center ( Site 3302)

    Ōta, Gunma, Japan 373-8550

    Recruiting now

  • Sapporo Medical University Hospital ( Site 3324)

    Sapporo, Hokkaido, Japan 060-8543

    Recruiting now

  • Kanazawa University Hospital ( Site 3308)

    Kanazawa, Ishikawa-ken, Japan 920-8641

    Recruiting now

  • St. Marianna University Hospital ( Site 3320)

    Kawasaki, Kanagawa, Japan 216-8511

    Recruiting now

  • Saiseikai Matsusaka Municipal Hospital ( Site 3311)

    Matsusaka, Mie-ken, Japan 515-8544

    Recruiting now

  • Miyagi Cancer Center ( Site 3301)

    Natori-shi, Miyagi, Japan 981-1293

    Recruiting now

  • Sendai Kousei Hospital ( Site 3300)

    Sendai, Miyagi, Japan 981-0914

    Recruiting now

  • Kansai Medical University Hospital ( Site 3312)

    Hirakata, Osaka, Japan 573-1191

    Recruiting now

  • Osaka Medical and Pharmaceutical University Hospital ( Site 3313)

    Takatsuki, Osaka, Japan 569-8686

    Recruiting now

  • Saitama Prefectural Cancer Center ( Site 3304)

    Kitaadachi-gun, Saitama, Japan 362-0806

    Recruiting now

  • Nippon Medical School Hospital ( Site 3306)

    Bunkyo, Tokyo, Japan 113-8603

    Recruiting now

  • Toho University Omori Medical Center ( Site 3319)

    Ōta-ku, Tokyo, Japan 143-8541

    Recruiting now

  • Tokyo Medical University Hospital ( Site 3307)

    Shinjuku, Tokyo, Japan 160-0023

    Recruiting now

  • National Center for Global Health and Medicine ( Site 3305)

    Shinjuku, Tokyo, Japan 162-8655

    Recruiting now

  • Chiba University Hospital ( Site 3322)

    Chiba, Japan 260-8677

    Recruiting now

  • Hiroshima City Hiroshima Citizens Hospital ( Site 3314)

    Hiroshima, Japan 730-8518

    Recruiting now

  • Saiseikai Kumamoto Hospital ( Site 3318)

    Kumamoto, Japan 861-4193

    Recruiting now

  • Niigata University Medical & Dental Hospital ( Site 3323)

    Niigata, Japan 951-8520

    Recruiting now

  • Osaka Metropolitan University Hospital ( Site 3321)

    Osaka, Japan 545-8586

    Recruiting now

  • Arké SMO S.A. de C.V. ( Site 0602)

    Mexico City, Mexico City, Mexico 06700

    Recruiting now

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Hematologia and Oncologia ( Site 0600)

    Monterrey, Nuevo León, Mexico 66460

    Recruiting now

  • Oaxaca Site Management Organization S.C. ( Site 0603)

    Oaxaca City, Mexico 68000

    Recruiting now

  • Ziekenhuis Gelderse Vallei ( Site 1705)

    Ede, Gelderland, Netherlands 6716 RP

    Recruiting now

  • Ziekenhuis St. Jansdal-Poli Longziekten ( Site 1701)

    Harderwijk, Gelderland, Netherlands 3844 DG

    Recruiting now

  • Isala, locatie Zwolle-Poli Longziekten ( Site 1700)

    Zwolle, Overijssel, Netherlands 8025 AB

    Recruiting now

  • Universitair Medisch Centrum Utrecht ( Site 1704)

    Utrecht, Netherlands 3584 CX

    Recruiting now

  • Auckland City Hospital ( Site 3400)

    Auckland, New Zealand 1023

    Recruiting now

  • The Medical City ( Site 3507)

    Pasig, National Capital Region, Philippines 1600

    Recruiting now

  • Lung Center of the Philippines-Pulmonary, Critical Care and Sleep Medicine ( Site 3503)

    Quezon City, National Capital Region, Philippines 1100

    Recruiting now

  • Veterans Memorial Medical Center-Section of Oncology ( Site 3505)

    Quezon City, National Capital Region, Philippines 1100

    Recruiting now

  • ST. LUKE'S MEDICAL CENTER-Medical oncology ( Site 3501)

    Quezon City, National Capital Region, Philippines 1102

    Recruiting now

  • Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1801)

    Gorlice, Lesser Poland Voivodeship, Poland 38-300

    Active, not recruiting

  • Pratia MCM Krakow ( Site 1808)

    Krakow, Lesser Poland Voivodeship, Poland 30-727

    Recruiting now

  • Uniwersytecki Szpital Kliniczny nr 4 w Lublinie ( Site 1805)

    Lublin, Lublin Voivodeship, Poland 20-090

    Recruiting now

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1800)

    Warsaw, Masovian Voivodeship, Poland 02-781

    Recruiting now

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1804)

    Przemyśl, Podkarpackie Voivodeship, Poland 37-700

    Recruiting now

  • Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 1809)

    Olsztyn, Warmian-Masurian Voivodeship, Poland 10-357

    Recruiting now

  • Centrul de Diagnostic si Tratament Provita. ( Site 1992)

    Bucharest, Bucharest, Romania 020335

    Recruiting now

  • Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1994)

    Craiova, Dolj, Romania 200542

    Recruiting now

  • Cabinet Medical Oncomed ( Site 1998)

    Timișoara, Timiș County, Romania 300239

    Recruiting now

  • SC ONCO CARD SRL ( Site 1995)

    Brasov, Romania 500052

    Recruiting now

  • Institutul Oncologic Cluj-Oncologie Medicala ( Site 1999)

    Cluj-Napoca, Romania 400015

    Recruiting now

  • Sigmedical Services SRL ( Site 1997)

    Suceava, Romania 720214

    Recruiting now

  • The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 3606)

    Bupyeong-gu, Incheon, South Korea 21431

    Recruiting now

  • Chonnam National University Hwasun Hospital-Pulmonology ( Site 3604)

    Hwasun, Jeonranamdo, South Korea 58128

    Completed

  • The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 3600)

    Suwon, Kyonggi-do, South Korea 16247

    Recruiting now

  • Pusan National University Yangsan Hospital-Lung Cancer Clinic ( Site 3603)

    Yangsan, Kyongsangnam-do, South Korea 50612

    Recruiting now

  • Yeungnam University Hospital ( Site 3607)

    Daegu, Taegu-Kwangyokshi, South Korea 42415

    Recruiting now

  • Keimyung University Dongsan Hospital ( Site 3611)

    Daegu, Taegu-Kwangyokshi, South Korea 42601

    Recruiting now

  • Chungnam national university hospital ( Site 3602)

    Junggu, Taejon-Kwangyokshi, South Korea 35015

    Recruiting now

  • Inha University Hospital ( Site 3610)

    Incheon, South Korea 22332

    Recruiting now

  • Kyung Hee University Hospital ( Site 3605)

    Seoul, South Korea 02447

    Recruiting now

  • Korea University Anam Hospital ( Site 3609)

    Seoul, South Korea 02841

    Recruiting now

  • The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3608)

    Seoul, South Korea 03312

    Recruiting now

  • Korea University Guro Hospital ( Site 3601)

    Seoul, South Korea 08308

    Recruiting now

  • Hospital Insular de Gran Canaria-Oncology ( Site 2019)

    Las Palmas de Gran Canaria, Las Palmas, Spain 35001

    Recruiting now

  • HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 2012)

    Madrid, Madrid, Comunidad de, Spain 28009

    Recruiting now

  • H.R.U Málaga - Hospital General-Oncology ( Site 2014)

    Málaga, Malaga, Spain 29011

    Recruiting now

  • Hospital Universitari Vall d Hebron ( Site 2010)

    Barcelona, Spain 08035

    Recruiting now

  • Hospital Universitario La Princesa ( Site 2020)

    Madrid, Spain 28006

    Recruiting now

  • Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2017)

    Madrid, Spain 28040

    Recruiting now

  • Hospital Universitario Virgen de la Victoria ( Site 2021)

    Málaga, Spain 29010

    Recruiting now

  • Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2015)

    Seville, Spain 41009

    Recruiting now

  • Ege Universitesi Hastanesi-Chest Diseases Department ( Site 2102)

    Bornova, İzmir, Turkey (Türkiye) 35100

    Recruiting now

  • Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2107)

    Adana, Turkey (Türkiye) 01140

    Recruiting now

  • SBU GULHANE EGITIM VE ARASTIRMA HASTANESI Onkoloji ( Site 2104)

    Ankara, Turkey (Türkiye) 06010

    Recruiting now

  • Hacettepe Universite Hastaneleri-oncology hospital ( Site 2101)

    Ankara, Turkey (Türkiye) 06230

    Recruiting now

  • Memorial Ankara Hastanesi-Medical Oncology ( Site 2106)

    Ankara, Turkey (Türkiye) 06520

    Recruiting now

  • Ankara Bilkent Şehir Hastanesi ( Site 2100)

    Ankara, Turkey (Türkiye) 06800

    Recruiting now

  • Medipol Mega Universite Hastanesi-oncology ( Site 2105)

    Istanbul, Turkey (Türkiye) 34214

    Recruiting now

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2103)

    Istanbul, Turkey (Türkiye) 34722

    Recruiting now

  • COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 2209)

    Cherkasy, Cherkasy Oblast, Ukraine 18009

    Active, not recruiting

  • Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 2210)

    Chernivtsi, Chernivetska Oblast, Ukraine 58013

    Recruiting now

  • Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2215)

    Kryvyi Rih, Dnipropetrovsk Oblast, Ukraine 50000

    Recruiting now

  • Communal Non-Commercial Enterprise "Prykarpatski Clinical On-Surgery department #2 ( Site 2202)

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine 76018

    Recruiting now

  • Kirovohrad Regional Oncology Center-Chemotherapy department ( Site 2204)

    Kropyvnytskyi, Kirovohrad Oblast, Ukraine 25011

    Recruiting now

  • Medical Center "MedOffice Group" ( Site 2219)

    Kiev, Kyivska Oblast, Ukraine 03022

    Recruiting now

  • Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2217)

    Lviv, Lviv Oblast, Ukraine 79059

    Recruiting now

  • Rivne Regional Clinical Hospital ( Site 2205)

    Rivne, Rivne Oblast, Ukraine 33007

    Completed

  • ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2920)

    Rivne, Rivne Oblast, Ukraine 33010

    Recruiting now

  • Communal Noncommercial Enterprise "Podillia Regional Oncolog-Cardiothoracic department ( Site 2211)

    Vinnytsia, Vinnytsia Oblast, Ukraine 21029

    Recruiting now

  • ME Volyn Regional Clinical Hospital of the Volyn Regional Council ( Site 2216)

    Lutsk, Volyn Oblast, Ukraine 43018

    Recruiting now

  • Milton Keynes Hospital ( Site 2304)

    Milton Keynes, Buckinghamshire, United Kingdom MK6 5LD

    Recruiting now

  • Royal Devon & Exeter Hospital-Oncology ( Site 2302)

    Exeter, Devon, United Kingdom EX2 5DW

    Recruiting now
See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

The main inclusion and exclusion criteria include but are not limited to the following:

Inclusion Criteria:

* Has histologically or cytologically confirmed diagnosis of non-small cell lung cancer (NSCLC)
* Has newly diagnosed Stage IIIB/IIIC NSCLC, not eligible for curative resection or curative chemotherapy/radiation as determined by a multidisciplinary tumor board and/or by radiation oncologist, surgeon, and medical oncologist or Stage IV (M1a, M1b, or M1c) by American Joint Committee on Cancer (AJCC) Staging Manual, Version 8
* Provides an archival tumor tissue sample (≤5 years) or newly obtained core, incisional, or excisional biopsy of a tumor lesion not previously irradiated to enable central laboratory testing of kirsten rat sarcoma (KRAS) G12C mutation status, PD-L1 status, and biomarker research
* If have had adverse events (AEs) due to previous anticancer therapies, must have recovered to \< Grade 1 or baseline
* If human immunodeficiency virus (HIV)-infected, must have well controlled HIV on antiretroviral therapy (ART)
* If Hepatitis B surface antigen (HBsAg) positive, have received Hepatitis B Virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load
* If a participant has a history of Hepatitis C virus (HCV) infection, HCV viral load is undetectable

Exclusion Criteria:

* Has diagnosis of small cell lung cancer. For mixed tumors, if small cell elements are present, the participant is ineligible
* Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease
* Has known history of, or active, neurologic paraneoplastic syndrome
* Has an active infection requiring systemic therapy, with exceptions
* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
* Has one or more of the following ophthalmological findings/conditions: intraocular pressure \>21 mmHg and/or any diagnosis of glaucoma, diagnosis of central serous retinopathy, retinal vein occlusion, or retinal artery occlusion, diagnosis of retinal degenerative disease
* Has received prior systemic anticancer therapy for their locally advanced or metastatic NSCLC
* Has received radiation therapy to the lung that is \>30 Gray within 6 months of start of study intervention
* Has received radiotherapy within 2 weeks of start of study intervention. Participants must have recovered from all radiation-related toxicities, not required corticosteroids, and not have had radiation pneumonitis
* Has known active central nervous system metastases and/or carcinomatous meningitis
* Known additional malignancy that is progressing or has required active treatment within the past 3 years
* Has active autoimmune disease that has required systemic treatment in the past 2 years
* Has history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease
* Is HIV-infected and has a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
* Has history of allogenic tissue/solid organ transplant
* Has not fully recovered from any effects of major surgical procedure

Updated 2026-06-15 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.