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Recruiting nowPhase 3Ages 18 Years and up

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Sponsor: National Cancer Institute (NCI) · NCT06422806 on ClinicalTrials.gov ↗

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Conditions studied

Metastatic Dedifferentiated LiposarcomaMetastatic Undifferentiated Pleomorphic SarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Unresectable Dedifferentiated LiposarcomaUnresectable Undifferentiated Pleomorphic Sarcoma

What it tests

  • Biospecimen Collectionprocedure
  • Diagnostic Imaging Testingprocedure
  • Doxorubicindrug
  • Echocardiography Testprocedure
  • Multigated Acquisition Scanprocedure
  • Pembrolizumabbiological

Where it's running256 sites

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona 85054

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Mahesh Seetharam(principal investigator)

  • Banner University Medical Center - Tucson

    Tucson, Arizona 85719

    Recruiting now

  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona 85719

    Recruiting now

  • Kaiser Permanente Dublin

    Dublin, California 94568

    Recruiting now
    • Site Public Contact(contact)877-642-4691
    • Tatjana Kolevska(principal investigator)

  • Kaiser Permanente-Fremont

    Fremont, California 94538

    Recruiting now

  • Kaiser Permanente Fresno Orchard Plaza

    Fresno, California 93720

    Recruiting now
    • Site Public Contact(contact)833-574-2273
    • Tatjana Kolevska(principal investigator)

  • Kaiser Permanente-Fresno

    Fresno, California 93720

    Recruiting now

  • UC San Diego Moores Cancer Center

    La Jolla, California 92093

    Recruiting now

  • Keck Medicine of USC Koreatown

    Los Angeles, California 90020

    Recruiting now
    • Site Public Contact(contact)213-388-0908
    • Mark Agulnik(principal investigator)

  • Los Angeles General Medical Center

    Los Angeles, California 90033

    Recruiting now

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California 90033

    Recruiting now
    • Site Public Contact(contact)323-865-0451
    • Mark Agulnik(principal investigator)

  • Cedars-Sinai Medical Center

    Los Angeles, California 90048

    Recruiting now

  • Kaiser Permanente- Modesto MOB II

    Modesto, California 95356

    Recruiting now
    • Site Public Contact(contact)877-642-4691
    • Tatjana Kolevska(principal investigator)

  • Kaiser Permanente-Modesto

    Modesto, California 95356

    Recruiting now

  • USC Norris Oncology/Hematology-Newport Beach

    Newport Beach, California 92663

    Recruiting now
    • Site Public Contact(contact)323-865-0451
    • Mark Agulnik(principal investigator)

  • Kaiser Permanente-Oakland

    Oakland, California 94611

    Recruiting now

  • Stanford Cancer Institute Palo Alto

    Palo Alto, California 94304

    Recruiting now

  • VA Palo Alto Health Care System

    Palo Alto, California 94304

    Suspended

  • Huntington Memorial Hospital

    Pasadena, California 91105

    Recruiting now
    • Site Public Contact(contact)626-535-2420
    • James S. Hu(principal investigator)

  • Kaiser Permanente-Roseville

    Roseville, California 95661

    Recruiting now

  • Kaiser Permanente Downtown Commons

    Sacramento, California 95814

    Recruiting now

  • Kaiser Permanente-South Sacramento

    Sacramento, California 95823

    Recruiting now

  • Kaiser Permanente-San Francisco

    San Francisco, California 94115

    Recruiting now

  • UCSF Medical Center-Mission Bay

    San Francisco, California 94158

    Recruiting now

  • Kaiser Permanente-Santa Teresa-San Jose

    San Jose, California 95119

    Recruiting now

  • Kaiser Permanente San Leandro

    San Leandro, California 94577

    Recruiting now

  • Kaiser San Rafael-Gallinas

    San Rafael, California 94903

    Recruiting now

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California 95051

    Recruiting now

  • Kaiser Permanente-Santa Rosa

    Santa Rosa, California 95403

    Recruiting now

  • Kaiser Permanente-South San Francisco

    South San Francisco, California 94080

    Recruiting now

  • Kaiser Permanente-Vallejo

    Vallejo, California 94589

    Recruiting now

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California 94596

    Recruiting now

  • UCHealth University of Colorado Hospital

    Aurora, Colorado 80045

    Recruiting now
    • Site Public Contact(contact)720-848-0650
    • Breelyn A. Wilky(principal investigator)

  • Poudre Valley Hospital

    Fort Collins, Colorado 80524

    Recruiting now
    • Site Public Contact(contact)970-297-6150
    • Breelyn A. Wilky(principal investigator)

  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado 80528

    Recruiting now

  • UCHealth Greeley Hospital

    Greeley, Colorado 80631

    Recruiting now

  • Medical Center of the Rockies

    Loveland, Colorado 80538

    Recruiting now
    • Site Public Contact(contact)970-203-7083
    • Breelyn A. Wilky(principal investigator)

  • Smilow Cancer Hospital-Derby Care Center

    Derby, Connecticut 06418

    Suspended

  • Smilow Cancer Hospital Care Center-Fairfield

    Fairfield, Connecticut 06824

    Suspended

  • Smilow Cancer Hospital Care Center at Greenwich

    Greenwich, Connecticut 06830

    Suspended

  • Smilow Cancer Hospital Care Center - Guilford

    Guilford, Connecticut 06437

    Suspended

  • Yale University

    New Haven, Connecticut 06520

    Suspended

  • Smilow Cancer Hospital Care Center at Long Ridge

    Stamford, Connecticut 06902

    Suspended

  • Smilow Cancer Hospital-Torrington Care Center

    Torrington, Connecticut 06790

    Suspended

  • Smilow Cancer Hospital Care Center-Trumbull

    Trumbull, Connecticut 06611

    Suspended

  • Smilow Cancer Hospital-Waterbury Care Center

    Waterbury, Connecticut 06708

    Suspended

  • Smilow Cancer Hospital Care Center - Waterford

    Waterford, Connecticut 06385

    Suspended

  • Beebe South Coastal Health Campus

    Millville, Delaware 19967

    Recruiting now

  • Helen F Graham Cancer Center

    Newark, Delaware 19713

    Recruiting now

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware 19713

    Recruiting now

  • Beebe Health Campus

    Rehoboth Beach, Delaware 19971

    Recruiting now

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida 33146

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • UM Sylvester Comprehensive Cancer Center at Coral Springs

    Coral Springs, Florida 33065

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida 33442

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida 32610

    Recruiting now

  • UM Sylvester Comprehensive Cancer Center at Hollywood

    Hollywood, Florida 33021

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • Mayo Clinic in Florida

    Jacksonville, Florida 32224-9980

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Mahesh Seetharam(principal investigator)

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida 33136

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida 33176

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

    North Miami, Florida 33181

    Recruiting now

  • UM Sylvester Comprehensive Cancer Center at Plantation

    Plantation, Florida 33324

    Recruiting now
    • Site Public Contact(contact)305-243-2647
    • Emily E. Jonczak(principal investigator)

  • Moffitt Cancer Center - McKinley Campus

    Tampa, Florida 33612

    Recruiting now

  • Moffitt Cancer Center

    Tampa, Florida 33612

    Recruiting now

  • Emory University Hospital Midtown

    Atlanta, Georgia 30308

    Recruiting now
    • Site Public Contact(contact)888-946-7447
    • Kenneth Cardona(principal investigator)

  • Kaiser Permanente Moanalua Medical Center

    Honolulu, Hawaii 96819

    Recruiting now

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho 83706

    Suspended

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho 83605

    Suspended

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho 83814

    Recruiting now

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho 83687

    Suspended

  • Kootenai Clinic Cancer Services - Post Falls

    Post Falls, Idaho 83854

    Recruiting now

  • Kootenai Clinic Cancer Services - Sandpoint

    Sandpoint, Idaho 83864

    Recruiting now

  • Advocate Outpatient Center - Aurora

    Aurora, Illinois 60506

    Recruiting now

  • Advocate Good Shepherd Hospital

    Barrington, Illinois 60010

    Recruiting now
    • Site Public Contact(contact)847-842-4847
    • Sigrun Hallmeyer(principal investigator)

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois 61704

    Recruiting now

  • Illinois CancerCare-Canton

    Canton, Illinois 61520

    Recruiting now

  • Illinois CancerCare-Carthage

    Carthage, Illinois 62321

    Recruiting now

  • Centralia Oncology Clinic

    Centralia, Illinois 62801

    Recruiting now

  • Northwestern University

    Chicago, Illinois 60611

    Recruiting now

  • University of Illinois

    Chicago, Illinois 60612

    Recruiting now
    • Site Public Contact(contact)312-355-3046
    • Vijayakrishna K. Gadi(principal investigator)

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois 60637

    Recruiting now

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois 60657

    Recruiting now
    • Site Public Contact(contact)773-296-5360
    • Sigrun Hallmeyer(principal investigator)

  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois 60014

    Recruiting now

  • Carle at The Riverfront

    Danville, Illinois 61832

    Recruiting now

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois 62526

    Recruiting now

  • Decatur Memorial Hospital

    Decatur, Illinois 62526

    Recruiting now

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois 60115

    Recruiting now

  • Illinois CancerCare-Dixon

    Dixon, Illinois 61021

    Recruiting now
    • Site Public Contact(contact)815-285-7800
    • Bryan A. Faller(principal investigator)

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois 60515

    Recruiting now

  • Carle Physician Group-Effingham

    Effingham, Illinois 62401

    Recruiting now

  • Crossroads Cancer Center

    Effingham, Illinois 62401

    Recruiting now

  • Advocate Sherman Hospital

    Elgin, Illinois 60123

    Recruiting now
    • Site Public Contact(contact)847-429-2907
    • Sigrun Hallmeyer(principal investigator)

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois 60126

    Recruiting now

  • Illinois CancerCare-Eureka

    Eureka, Illinois 61530

    Recruiting now

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois 61401

    Recruiting now

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois 60134

    Recruiting now

  • Northwestern Medicine Glenview Outpatient Center

    Glenview, Illinois 60026

    Recruiting now
    • Site Public Contact(contact)312-695-1102
    • Seth M. Pollack(principal investigator)

  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois 60030

    Recruiting now
    • Site Public Contact(contact)312-695-1102
    • Seth M. Pollack(principal investigator)

  • Ingalls Memorial Hospital

    Harvey, Illinois 60426

    Recruiting now

  • Advocate South Suburban Hospital

    Hazel Crest, Illinois 60429

    Recruiting now
    • Site Public Contact(contact)708-799-9995
    • Sigrun Hallmeyer(principal investigator)

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois 61443

    Recruiting now

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois 60045

    Recruiting now

  • AMG Libertyville - Oncology

    Libertyville, Illinois 60048

    Recruiting now

  • Condell Memorial Hospital

    Libertyville, Illinois 60048

    Recruiting now

  • Illinois CancerCare-Macomb

    Macomb, Illinois 61455

    Recruiting now

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois 61938

    Recruiting now

  • Edward Hospital/Cancer Center

    Naperville, Illinois 60540

    Recruiting now
    • Site Public Contact(contact)630-646-6075
    • Samir D. Undevia(principal investigator)

  • UC Comprehensive Cancer Center at Silver Cross

    New Lenox, Illinois 60451

    Recruiting now

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois 62269

    Recruiting now

  • Advocate Christ Medical Center

    Oak Lawn, Illinois 60453-2699

    Recruiting now
    • Site Public Contact(contact)800-323-8622
    • Sigrun Hallmeyer(principal investigator)

  • Northwestern Medicine Orland Park

    Orland Park, Illinois 60462

    Recruiting now

  • University of Chicago Medicine-Orland Park

    Orland Park, Illinois 60462

    Recruiting now

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois 61350

    Recruiting now

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois 60068

    Recruiting now
    • Site Public Contact(contact)847-384-3621
    • Sigrun Hallmeyer(principal investigator)

  • Illinois CancerCare-Pekin

    Pekin, Illinois 61554

    Recruiting now

  • Illinois CancerCare-Peoria

    Peoria, Illinois 61615

    Recruiting now

  • Illinois CancerCare-Peru

    Peru, Illinois 61354

    Recruiting now

  • Edward Hospital/Cancer Center?Plainfield

    Plainfield, Illinois 60585

    Recruiting now

  • Illinois CancerCare-Princeton

    Princeton, Illinois 61356

    Recruiting now

  • Southern Illinois University School of Medicine

    Springfield, Illinois 62702

    Recruiting now
    • Site Public Contact(contact)217-545-7929
    • Bryan A. Faller(principal investigator)

  • Springfield Clinic

    Springfield, Illinois 62702

    Recruiting now
    • Site Public Contact(contact)800-444-7541
    • Bryan A. Faller(principal investigator)

  • Springfield Memorial Hospital

    Springfield, Illinois 62781

    Recruiting now

  • Carle Cancer Center

    Urbana, Illinois 61801

    Recruiting now

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois 60555

    Recruiting now

  • Illinois CancerCare - Washington

    Washington, Illinois 61571

    Recruiting now

  • UChicago Medicine Northwest Indiana

    Crown Point, Indiana 46307

    Recruiting now

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana 46202

    Recruiting now

  • Sidney and Lois Eskenazi Hospital

    Indianapolis, Indiana 46202

    Recruiting now

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa 50023

    Recruiting now
    • Site Public Contact(contact)515-241-3305
    • Seema Harichand-Herdt(principal investigator)

  • Saint Anthony Regional Hospital

    Carroll, Iowa 51401

    Recruiting now

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa 50325

    Recruiting now
    • Site Public Contact(contact)515-241-3305
    • Seema Harichand-Herdt(principal investigator)

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa 50309

    Recruiting now
    • Site Public Contact(contact)515-241-3305
    • Seema Harichand-Herdt(principal investigator)

  • Broadlawns Medical Center

    Des Moines, Iowa 50314

    Recruiting now
    • Site Public Contact(contact)515-282-2200
    • Seema Harichand-Herdt(principal investigator)

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa 50314

    Recruiting now
    • Site Public Contact(contact)515-241-3305
    • Seema Harichand-Herdt(principal investigator)

  • UI Healthcare Mission Cancer and Blood - Fort Dodge

    Fort Dodge, Iowa 50501

    Recruiting now

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa 52242

    Recruiting now
    • Site Public Contact(contact)800-237-1225
    • John M. Rieth(principal investigator)

  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    Waukee, Iowa 50263

    Recruiting now
    • Site Public Contact(contact)515-241-3305
    • Seema Harichand-Herdt(principal investigator)

  • The James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky 40202

    Recruiting now
    • Site Public Contact(contact)502-562-3429
    • Rohit Kumar(principal investigator)

  • UofL Health Medical Center Northeast

    Louisville, Kentucky 40245

    Recruiting now

  • Louisiana Hematology Oncology Associates LLC

    Baton Rouge, Louisiana 70809

    Suspended

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215

    Recruiting now
    • Site Public Contact(contact)877-442-3324
    • Candace L. Haddox(principal investigator)

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan 48109

    Recruiting now

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan 48183

    Recruiting now

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan 48038

    Recruiting now

  • Henry Ford Medical Center-Fairlane

    Dearborn, Michigan 48126

    Recruiting now

  • Henry Ford Hospital

    Detroit, Michigan 48202

    Recruiting now

  • Allegiance Health

    Jackson, Michigan 49201

    Recruiting now

  • Henry Ford Medical Center-Columbus

    Novi, Michigan 48377

    Recruiting now

  • Henry Ford West Bloomfield Hospital

    West Bloomfield, Michigan 48322

    Recruiting now

  • Henry Ford Wyandotte Hospital

    Wyandotte, Michigan 48192

    Recruiting now

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota 56601

    Recruiting now

  • Mercy Hospital

    Coon Rapids, Minnesota 55433

    Recruiting now

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota 56636

    Recruiting now

  • Essentia Health Cancer Center

    Duluth, Minnesota 55805

    Recruiting now

  • Fairview Southdale Hospital

    Edina, Minnesota 55435

    Recruiting now

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota 55746

    Recruiting now
    • Site Public Contact(contact)218-786-3308
    • Bret E. Friday(principal investigator)

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota 55407

    Recruiting now

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905

    Recruiting now
    • Site Public Contact(contact)855-776-0015
    • Mahesh Seetharam(principal investigator)

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota 55416

    Recruiting now

  • Regions Hospital

    Saint Paul, Minnesota 55101

    Recruiting now

  • United Hospital

    Saint Paul, Minnesota 55102

    Recruiting now

  • Essentia Health Sandstone

    Sandstone, Minnesota 55072

    Recruiting now

  • Essentia Health Virginia Clinic

    Virginia, Minnesota 55792

    Recruiting now

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri 63141

    Recruiting now

  • Washington University School of Medicine

    St Louis, Missouri 63110

    Recruiting now

  • Siteman Cancer Center-South County

    St Louis, Missouri 63129

    Recruiting now

  • Community Hospital of Anaconda

    Anaconda, Montana 59711

    Recruiting now

  • Billings Clinic Cancer Center

    Billings, Montana 59101

    Recruiting now

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana 59715

    Recruiting now

  • Benefis Sletten Cancer Institute

    Great Falls, Montana 59405

    Recruiting now

  • Logan Health Medical Center

    Kalispell, Montana 59901

    Recruiting now

  • Community Medical Center

    Missoula, Montana 59804

    Recruiting now

  • Nebraska Medicine-Bellevue

    Bellevue, Nebraska 68123

    Recruiting now

  • Nebraska Medicine-Village Pointe

    Omaha, Nebraska 68118

    Recruiting now
    • Site Public Contact(contact)402-559-5600
    • Omar K. Abughanimeh(principal investigator)

  • University of Nebraska Medical Center

    Omaha, Nebraska 68198

    Recruiting now

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire 03756

    Recruiting now

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey 07920

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Robert Maki(principal investigator)

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey 07645

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Robert Maki(principal investigator)

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87106

    Recruiting now

  • Roswell Park Cancer Institute

    Buffalo, New York 14263

    Recruiting now

  • Northwell Health/Center for Advanced Medicine

    Lake Success, New York 11042

    Recruiting now
    • Site Public Contact(contact)516-734-8896
    • Tony Philip(principal investigator)

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York 10016

    Recruiting now

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Robert Maki(principal investigator)

  • University of Rochester

    Rochester, New York 14642

    Recruiting now
    • Site Public Contact(contact)585-275-5830
    • Adrienne I. Victor(principal investigator)

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York 10461

    Recruiting now

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York 10467

    Recruiting now

  • Memorial Sloan Kettering Nassau

    Uniondale, New York 11553

    Recruiting now
    • Site Public Contact(contact)212-639-7592
    • Robert Maki(principal investigator)

  • Duke University Medical Center

    Durham, North Carolina 27710

    Recruiting now
    • Site Public Contact(contact)888-275-3853
    • Richard F. Riedel(principal investigator)

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota 58501

    Recruiting now

  • Sanford Broadway Medical Center

    Fargo, North Dakota 58122

    Recruiting now

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota 58122

    Recruiting now

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio 44011

    Recruiting now
    • Site Public Contact(contact)800-641-2422
    • Ankit Mangla(principal investigator)

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio 44122

    Recruiting now

  • Miami Valley Hospital South

    Centerville, Ohio 45459

    Recruiting now

  • Case Western Reserve University

    Cleveland, Ohio 44106

    Recruiting now

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195

    Recruiting now

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210

    Recruiting now

  • Miami Valley Hospital

    Dayton, Ohio 45409

    Recruiting now

  • Premier Blood and Cancer Center

    Dayton, Ohio 45409

    Recruiting now
    • Site Public Contact(contact)937-276-8320
    • Tarek M. Sabagh(principal investigator)

  • Miami Valley Hospital North

    Dayton, Ohio 45415

    Recruiting now

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio 45005-1066

    Recruiting now

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio 45331

    Recruiting now
    • Site Public Contact(contact)937-569-7515
    • Tarek M. Sabagh(principal investigator)

  • Upper Valley Medical Center

    Troy, Ohio 45373

    Recruiting now

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma 73104

    Recruiting now

  • Saint Alphonsus Cancer Care Center-Ontario

    Ontario, Oregon 97914

    Suspended

  • Oregon Health and Science University

    Portland, Oregon 97239

    Recruiting now

  • Pennsylvania Hospital

    Philadelphia, Pennsylvania 19107

    Recruiting now

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania 19107

    Recruiting now

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania 19111

    Recruiting now
    • Site Public Contact(contact)215-728-4790
    • Teresa Lee(principal investigator)

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania 15212

    Recruiting now
    • Site Public Contact(contact)877-284-2000
    • Larisa Greenberg(principal investigator)

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania 15232

    Recruiting now
    • Site Public Contact(contact)412-647-8073
    • Melissa A. Burgess(principal investigator)

  • Medical University of South Carolina

    Charleston, South Carolina 29425

    Recruiting now

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota 57104

    Recruiting now

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota 57117-5134

    Recruiting now

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee 37232

    Recruiting now
    • Site Public Contact(contact)800-811-8480
    • Elizabeth J. Davis(principal investigator)

  • UT MD Anderson Cancer Center

    Houston, Texas 77030

    Recruiting now

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908

    Recruiting now

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia 23298

    Recruiting now

  • ThedaCare Regional Cancer Center

    Appleton, Wisconsin 54911

    Recruiting now

  • Duluth Clinic Ashland

    Ashland, Wisconsin 54806

    Recruiting now

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin 53105

    Recruiting now

  • Aurora Saint Luke's South Shore

    Cudahy, Wisconsin 53110

    Recruiting now

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin 54701

    Recruiting now

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin 53022

    Recruiting now

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin 53024

    Recruiting now

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin 54311

    Recruiting now

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin 53142

    Recruiting now

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin 54143

    Recruiting now

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin 54449

    Recruiting now

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin 53209

    Recruiting now

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin 53215

    Recruiting now

  • Medical College of Wisconsin

    Milwaukee, Wisconsin 53226

    Recruiting now
    • Site Public Contact(contact)414-805-3666
    • John A. Charlson(principal investigator)

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin 53233

    Recruiting now

  • ProHealth D N Greenwald Center

    Mukwonago, Wisconsin 53149

    Recruiting now
    • Site Public Contact(contact)[email protected]
    • Timothy R. Wassenaar(principal investigator)

  • ProHealth Oconomowoc Memorial Hospital

    Oconomowoc, Wisconsin 53066

    Recruiting now
    • Site Public Contact(contact)262-928-7878
    • Timothy R. Wassenaar(principal investigator)

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin 54904

    Recruiting now

  • Aurora Cancer Care-Racine

    Racine, Wisconsin 53406

    Recruiting now

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin 53081

    Recruiting now

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin 54482

    Recruiting now

  • Aurora Medical Center in Summit

    Summit, Wisconsin 53066

    Recruiting now

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin 54241

    Recruiting now

  • ProHealth Waukesha Memorial Hospital

    Waukesha, Wisconsin 53188

    Recruiting now
    • Site Public Contact(contact)262-928-7632
    • Timothy R. Wassenaar(principal investigator)

  • UW Cancer Center at ProHealth Care

    Waukesha, Wisconsin 53188

    Recruiting now

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin 53226

    Recruiting now

  • Aurora West Allis Medical Center

    West Allis, Wisconsin 53227

    Recruiting now

  • Marshfield Medical Center - Weston

    Weston, Wisconsin 54476

    Recruiting now
11 international sites

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, Canada T2N 5G2

    Recruiting now

  • Cross Cancer Institute

    Edmonton, Alberta, Canada T6G 1Z2

    Recruiting now
    • Site Public Contact(contact)780-432-8500
    • Branawan Gowrishankar(principal investigator)

  • BCCA-Vancouver Cancer Centre

    Vancouver, British Columbia, Canada V5Z 4E6

    Recruiting now
    • Site Public Contact(contact)888-939-3333
    • Alannah Smrke(principal investigator)

  • CancerCare Manitoba

    Winnipeg, Manitoba, Canada R3E 0V9

    Recruiting now

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, Canada L8V 5C2

    Recruiting now
    • Site Public Contact(contact)905-387-9495
    • Courtney Coschi(principal investigator)

  • Ottawa Hospital and Cancer Center-General Campus

    Ottawa, Ontario, Canada K1H 8L6

    Recruiting now
    • Site Public Contact(contact)613-761-4395
    • Garth A. Nicholas(principal investigator)

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, Canada M5G 2M9

    Recruiting now

  • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

    Québec, Quebec, Canada G1R 2J6

    Recruiting now

  • Pan American Center for Oncology Trials LLC - Dorado

    Dorado, Puerto Rico 00646

    Recruiting now

  • Pan American Center for Oncology Trials LLC

    San Juan, Puerto Rico 00902

    Recruiting now

  • Pan American Center for Oncology Trials LLC - Ciudadela

    San Juan, Puerto Rico 00909

    Recruiting now
See the official eligibility language

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Patient must be \>= 18 years of age
* Patient must have a confirmed histopathologic diagnosis of dedifferentiated liposarcoma (DDLPS), undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma. Because UPS can sometimes exist in a spectrum among related diagnoses, the following additional diagnostic will be allowed, but not limited to:

  * Pleomorphic sarcoma with inflammation or with limited areas of differentiation
  * Pleomorphic sarcoma with giant cells
  * Malignant fibrous histiocytoma (including storiform-pleomorphic and inflammatory subtypes)
  * Myxofibrosarcoma
  * Poorly differentiated sarcoma not otherwise specified (NOS)
  * Undifferentiated spindle cell sarcoma
  * Poorly differentiated spindle cell sarcoma NOS Any of these subtypes may have areas of focal myogenic differentiation
* Patient must have metastatic or unresectable sarcoma
* Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A patient of childbearing potential is defined as anyone, regardless of whether they have undergone tubal ligation, who meets the following criteria:

  * Has achieved menarche at some point
  * Has not undergone a hysterectomy or bilateral oophorectomy; or
  * Has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
* Patient must not expect to conceive or father children by using an accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study. Contraception measures must continue for 6 months after the last dose of doxorubicin for patients of child bearing potential and for 3 months after the last dose of doxorubicin for male patients with partners of child bearing potential. Males with pregnant partners should use condoms during doxorubicin treatment and for at least 10 days after the last dose of doxorubicin. Contraception measures must also continue for 4 months after the last dose of pembrolizumab for patients of child bearing potential
* Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible
* Patient must have a left ventricular ejection fraction (LVEF) \> 50% by either MUGA scan or echocardiogram obtained within 28 days prior to randomization
* Absolute neutrophil count (ANC) ≥ 1,500 cells/uL (must be obtained ≤ 7 days prior to protocol randomization)
* Platelets ≥ 75,000 cells/uL (must be obtained ≤ 7 days prior to protocol randomization)
* Total bilirubin \< 1.2 mg/dL (must be obtained ≤ 7 days prior to protocol randomization)
* Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase \[SGPT\]) ≤ 3.0 × institutional upper limit of normal (ULN) (must be obtained ≤ 7 days prior to protocol randomization)
* Creatinine clearance ≥ 30 mL/min according to the Cockcroft-Gault formula (must be obtained ≤ 7 days prior to protocol randomization)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial
* For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
* Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
* Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression
* Patients with new or progressive brain metastases (active brain metastases) or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required and is unlikely to be required during the first cycle of therapy
* Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
* Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
* Patient must not have a history of or active interstitial lung disease
* Patient must have measurable disease. Baseline imaging must include a chest computed tomography (CT). Imaging should be inclusive of all measurable and non-measurable disease and must be obtained within 28 days prior to randomization. Imaging must be available for uploading to Transfer of Images and Data (TRIAD)

  * NOTE: CT with (w/) contrast preferred, chest CT without contrast is acceptable, CT portion of positron emission tomography (PET) may be acceptable. Magnetic resonance imaging (MRI) is acceptable for measuring other sites of disease
* Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
* Patient must not have had prior treatment with an anthracycline
* Patient must not have a diagnosis of clinically significant immunodeficiency or an autoimmune disorder requiring the patient to use systemic steroid chronically, or systemic steroids within 7 days prior to randomization
* Patient must not have a known history of active TB (Bacillus Tuberculosis)
* Patient must not have a known hypersensitivity to doxorubicin or pembrolizumab or any of their excipients
* Patients who have received prior chemotherapy, targeted small molecule therapy or radiation therapy must have recovered from the prior therapy at the time of randomization
* Patient must have recovered adequately from any prior major surgery prior to randomization
* Patient must not have had prior pericardial or mediastinal radiation
* Patient must not have received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2 or anti-CTLA4 agent
* Patient must not have an autoimmune or other disease that requires the use of daily corticosteroids of \> 10 mg of prednisone (or equivalent). Patients who are on an active steroid taper at the time of randomization must finish prior to beginning study treatment. Patients who require inhaled or topical steroids are eligible

Updated 2026-06-18 on ClinicalTrials.gov. Always confirm current details with the study team or your oncologist.