B7-H3 NIR Imaging for Osteosarcoma Surgery

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* 1\. Patients with histologically confirmed osteosarcoma of the limbs.
* 2\. the patients has not undergone tumor resection.
* 3\. Age between 18 and 60 years old.
* 4\. No prior systemic treatment for osteosarcoma.
* 5\. Measurable disease as assessed by imaging studies (e.g., MRI, CT).
* 6\. Adequate bone marrow, liver, and renal function.
* 7\. Written informed consent obtained from the patient.

Exclusion Criteria:

* 1\. History of other malignancies within the past 5 years.
* 2\. Pregnancy or lactation.
* 3\. Known hypersensitivity to any component of the B7H3-based NIR imaging agent.
* 4\. Uncontrolled intercurrent illness that would preclude safe study participation.
* 5\. Prior radiation therapy to the target lesion.
* 6\. Any medical condition that would compromise the patient's ability to undergo surgery or comply with study procedures.
* 7.Patients not able to sign the Informed Consent.