Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

* Individuals must meet all of the following inclusion criteria in order to be eligible to participate in the study:

  * Provide signed and dated informed consent form
  * Willing to comply with all study procedures and be available for the duration of the study
  * Male or female, Male or female, aged ≥18 years of age
  * Patients with pathologically confirmed STS (Trunk and extremity sarcoma only)
  * Scheduled for neoadjuvant RT for STS

    o Both standard and hypofractionation schedules are permitted.
  * Willing to comply with all study procedures and be available for the duration of the study

Exclusion Criteria:

* An individual who meets any of the following criteria will be excluded from participation in this study:

  * Pregnancy or lactation
  * Known allergic reactions to any component of Definity
  * Has STS that is too large for ultrasound imaging (e.g. its short axis is larger than 10 cm at the depth of 2 cm)
  * Has other primary cancers requiring systemic treatment.
  * Has metastatic disease at presentation
  * Had prior RT to the area