Comparison of the Effects of Needle Biopsy Tract Resection and Non-resection on Recurrence Rate in Patients With Primary Extremity Sarcoma

Shown exactly as written on ClinicalTrials.gov. Your oncologist is the right person to judge whether it fits your situation.

Inclusion Criteria:

1. Histologically confirmed diagnosis of primary bone or soft tissue sarcoma of the extremities (or highly suspected sarcoma);
2. Candidate for limb-sparing surgery and capable of en-bloc resection;
3. Age ≥ 5 years;
4. ECOG performance status 0-2;
5. Able to understand and sign informed consent.

Exclusion Criteria:

1. Presence of distant metastasis (e.g., lung, bone, or other sites) or unresectable skip lesions;
2. Patients deemed, based on preoperative multidisciplinary team (MDT) evaluation, unlikely to achieve adequate surgical margins and therefore only eligible for debulking or palliative surgery;
3. Patients with inconclusive needle biopsy results requiring open biopsy for definitive diagnosis;
4. Patients requiring amputation;
5. Patients who have received prior treatment for the tumor at non-participating centers;
6. Patients with an expected survival of less than 2 years;
7. Patients in whom the biopsy tract completely lies within the planned tumor resection field;
8. Patients who refuse to provide written informed consent.